... of the Second Xiangya Hospital of Central South University (IRB protocol number: S031). The methods described in this study were carried out in accordance with the approved guidelines. Osteosarcoma CRISPR-Cas9 CD44 Drug resistance Gene therapy Osteosarcoma is the most common primary malignant...

...Jianzhong Ai; Yong He; Mingxia Zheng; Yi Wen; Huan Zhang; Fangyang Huang; Ye Zhu Background/Aims: Cardiovascular diseases (CVD) are the leading causes for human mortality. However, the effective treatment for these diseases are still lacking. Currently, gene therapy could be a potential way...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Osteosarcoma CRISPR-Cas9 Meta-analysis CD44 Metastases Gene therapy Osteosarcoma is a common malignant primary tumor of bone, which mainly affects children...

... and gene therapy for many pulmonary diseases. Recently, it was shown that phosphorylation of surface-exposed tyrosine residues from AAV capsid targets the viral particles for ubiquitination and proteasome-mediated degradation, and mutations of these tyrosine residues lead to highly efficient vector...

...-bone healing TOB1 Gene therapy Mesenchymal stem cells MSCs were isolated from the tibia and femur of 12 week old healthy male Sprague-Dawley rats (purchased from the Experimental Animal Department of Shanghai Medical College of Fudan University) as previously described [ 20 ]. Briefly...

.... Enhancing endothelial integrity represents a novel therapeutic strategy for ALI/ARDS. Endothelial progenitor cells (EPCs) have been reported to participate in endothelial repair of ALI and also serve as a tool for gene therapy. Further, bone morphogenetic protein 2 (BMP2) is an essential signaling molecule...

... features that make it particularly attractive as a vector for pulmonary gene therapy. The 37/67-kDa laminin has been identified as a cellular receptor for AAV8 and it is highly expressed in respiratory epithelial cells [ 15 ]. Furthermore, Boutin et al. [ 16 ] demonstrated that seroprevalence of antibodies...

... and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, 3Biomembrane Laboratory, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Buenos Aires Key Words Lipopolymers Mice Lung Mechanics Gene therapy Abstract...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Lentiviral vectors Quinone reductase 2 Vascular smooth muscle cells Neointimal formation Gene therapy * The first two authors contributed equally to this work Cellular...

... to in the content or advertisements. Lentivirus Neointimal formation Endothelial regrowth Gene therapy Original Paper Cellular Physiology Cell Physiol Biochem 2010;26:441-448 and Biochemistry Accepted: June 25, 2010 Lentivirus-mediated RNAi Targeting CREB Binding Protein Attenuates Neointimal Formation...