.... Among these changes, dysregulation of microRNAs (miRNAs) usually occurs in cancer cells and is responsible for induction of drug resistance. Methods: Expression of miR-494 in gastric cancer tissues and cell lines was detected by quantitative reverse transcriptase real time PCR (qRT-PCR) analysis. Effect...

...Cheng Zhang; Yu Liang; Ming-Hui Ma; Kun-Zhe Wu; Chun-Dong Zhang; Dong-Qiu Dai Background/Aims: MicroRNAs have a significant role in the tumorigenesis and progression of cancers, including gastric cancer (GC). Our study aimed to identify a novel biomarker to predict the prognosis of patients with GC...

... and metastasis, is a crucial obstacle to successful chemotherapy for patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been found to play various roles in cancer. This study aimed to investigate the effect of XLOC_006753 on the development of MDR in GC cells. Methods: The expression levels...

...Xiaolan You; Yuanjie Wang; Jian Wu; Qinghong Liu; Dehu Chen; Dong Tang; Daorong Wang Background/Aims: Increased expression of galectin-1 (Gal-1) in gastric cancer (GC) promotes metastasis and correlates with poor prognosis. The mechanisms by which Gal-1 promotes GC metastasis remain unknown...

... cancer cells, especially gastric cancer. However, the effects of PepE on the metastasis of poorly-differentiated gastric cancer cells and the underlying molecular mechanisms have not been well elucidated. Methods: We evaluated PepE effects on gastric cancer cell invasion and migration in vitro via wound...

...Tingting Huang; Dian Liu; Yihua Wang; Piao Li; Li Sun; Huihua Xiong; Yuhong Dai; Man Zou; Xianglin Yuan; Hong Qiu Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest...

...Yongfan Xin; Shili Ning; Liang Zhang; Ming Cui Background/Aims: Lymph node metastasis is the primary cause of cancer-related death among patients with gastric cancer (GC), and cell division cycle 27 (CDC27) promotes the metastasis and epithelial-mesenchymal transition in many cancers. Till now...

...-3p expression in human gastric cancer (GC). However, the reasons of this dysregulation remain largely unclear. Methods: Bisulfite sequence analysis was performed to explore the methylation status of the promoter region of miR-338-3p. Cell wound-healing and transwell assays were performed to examine...

...Yanchun Jin; Chunming Yong; Keyu Ren; Dan Li; Hao Yuan Background/Aims: In this study, we investigated the effect of post-surgical parenteral nutrition on patients with gastric cancer (GC) and its possible mechanism. Methods: A total of 108 patients were invited to assess for eligibility and 28...

...Xudong Peng; Qingjie Kang; Rui Wan; Ziwei Wang Background/Aims: Previous studies demonstrated that HOXC9 acts as an oncogene in several tumors. The aim of this study was to explore whether HOXC9 promotes gastric cancer (GC) progression and elucidate the underlying molecular mechanisms. Methods...

...Jingya Wang; Xuwen Guan; Yue Zhang; Shaohua Ge; Le Zhang; Hongli Li; Xia Wang; Rui Liu; Tao Ning; Ting Deng; Haiyang Zhang; Xiangli Jiang; Yi Ba; Dingzhi Huang Background/Aims: The malignant biological behavior of gastric cancer(GC) is not only determined by cancer cells alone, but also closely...

...Junfeng Yin; Ze Ji; Yidong Hong; Ziyan Song; Nan Hu; Min Zhuang; Baoxiang Bian; Yi Liu; Fenglei Wu Background/Aims: To identify new treatment strategies for gastric cancer and to elucidate the mechanism underlying its pathophysiology, we transfected sh-MARCH8 into the human gastric cancer cell...

...Jiaojiao Hu; Yingying Qian; Lipan Peng; Ling Ma; Tianzhu Qiu; Yiqian Liu; Xiao Li; Xiaofeng Chen Background/Aims: LncRNA EGFR-AS1 is an antisense transcript of EGFR, which plays a key role in gastric cancer progression. This study was aimed to explore the effects of lncRNA EGFR-AS1 on GC...

...Bin Wang; Lei Qin; Mei Ren; Hao Sun Background/Aims: Gastric cancer (GC) is one of the most common and lethal varieties of cancers. Anticancer activities of anti-CTLA-4 and anti-PD-1 antibodies have been explored in different cancers, including GC. The study aimed to explore the role of combination...

... compound in danggui , is a potential antitumor agent for various cancer types. However, its clinical effect and mechanism in the treatment of gastric cancer remain undetermined. Methods: The in vivo protective effect of danggui in patients with gastric cancer were validated using data from Taiwan’s...

... the clinical significance of potentially functional single nucleotides polymorphisms (SNPs) in antioxidative enzymes, GPxs and CAT , in stages II and III gastric cancer patients. Methods: A total of 591 gastric cancer patients who had radical gastrectomy were recruited. 207 patients received platinum...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gastric cancer Neogenin-1 Epithelial mesenchymal transition Zinc finger E-box-binding homeobox 1 Rac1/PI3K/AKT Gastric cancer (GC) has...

...Hongtao Hu; Zongchang Song; Quanjun Yao; Xiang Geng; Li Jiang; Chenyang Guo; Hailiang Li Background/Aims: Gastric cancer is a highly aggressive tumor containing cancer stem cells (CSCs), which participate in tumor initiation, therapeutic resistance, and tumor relapse. Proline-rich protein 11...

...Zehong Chen; Jialin Wu; Wensheng Huang; Jianjun Peng; Jinning Ye; Liang Yang; YuJie Yuan; Chuangqi Chen; Changhua Zhang; Shirong Cai; Yulong He; Suijing Wu; Wu Song Background/Aims: Gastric cancer (GC) is a common malignancy with a global incidence that ranks fourth among all tumor types...

...Yu He; Yugang Ge; Mingkun Jiang; Jundong Zhou; Dakui Luo; Hao Fan; Liang Shi; Linling Lin; Li Yang Background/Aims: Gastric cancer (GC) is one of the most prevalent digestive malignancies. MicroRNAs (miRNAs) are involved in multiple cellular processes, including oncogenesis, and miR-592 itself...