... treatment in Traditional Mongolian Medicine. The flavonoid quercetin and its glycoside rutin, which exert anti-diabetic properties in vivo by interfering with insulin signaling in peripheral target tissues, are constituents of these extracts. This study was performed to better understand short- and long...

...Yuan Hao; Cindy S.T. Cheung; Wallace C.Y. Yip; Wing-hung Ko Background/Aims: Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined...

...Ken-ichi Nakajima; Naomi Niisato; Yoshinori Marunaka We have recently reported that Na + /K + /2Cl - cotransporter isoform 1 (NKCC1) plays an essential role in nerve growth factor (NGF)-induced neurite outgrowth in PC12D cells. On the other hand, it has been reported that dietary flavonoids...

...Eung-Ryoung Lee; Jung-Hyun Kim; Hye Yeon Choi; Kilsoo Jeon; Ssang-Goo Cho Although flavonoids exhibit a variety of beneficial biological activities, the exact molecular mechanism of the cellular effects is still not fully explained. In this study, we investigated the molecular mechanism...

...Horst Fischer; Beate Illek The flavone apigenin has been previously selected as a potent pharmacological activator of the CFTR Cl - channel, however, its utility for the activation of CFTR in vivo is expected to be limited because flavonoids are readily metabolized. We therefore investigated...

...Bruno Guigas; Roula Naboulsi; Gloria R. Villanueva; Nellie Taleux; José M. Lopez-Novoa; Xavier M. Leverve; Mohamad-Yehia El-Mir Background/Aims: The flavonoid silibinin has been reported to be beneficial in several hepatic disorders. Recent evidence also suggests that silibinin could be beneficial...