...Hansong Du; Yu Wang; Zhengfeng Zhang; Jing Yang; Jie Zhang; Ying Zhang Aims: To explore the explicit role of fibronectin (FN) isforms in atherosclerotic lesions and the underlying mechanisms. Methods and Results: Inducible stable expression was performed, and similar results were observed between...

... expression of collagen and fibronectin by western blot, quantitative real-time RT-PCR (RT-qPCR), immunofluorescence staining and histopathological examination. SSc mouse model induced by bleomycin was used to evaluate the effects of the drug in vivo . Results: Compared to normal fibroblast (NF...

..., the mechanisms through which GLP-1 modulates renal function remained illdefined. The present study investigated the putative mechanisms underlying effects of exendin-4, a GLP-1 analog, on mesangial cell proliferation and fibronectin. Methods: Rat mesangial cells (MCs) were treated with exendin-4 under high...

... of human tumor cells. However, BBR's anti-angiogenesis property and its clinical potential as an inhibitor of tumor angiogenesis in breast cancer cells have not been fully elucidated. Here, we investigated the effect of BBR on TPA-induced VEGF and fibronectin (FN) as well as VEGF-induced FN in breast...

... investigate the role of inorganic phosphate in stimulating fibronectin (FN) synthesis in akidney fibroblast cell line (NRK-49F). We find that phosphate increases FN abundance andmessage in a dose–dependent fashion and that both ERK1/2 and AKT are important signalingpathways that mediate phosphate-dependent FN...

... the underlying mechanism of KAI1/CD82-mediated changes in cell adhesion to the extracellular matrix using human prostate cancer cells. We found that high KAI1/CD82 expression attenuated short-term cell adhesion to uncoated- or fibronectin-coated plates. Moreover, high KAI1/CD82 expression generated...

...Cristina Rodríguez-Juan; Paz de la Torre; Inmaculada García-Ruiz; Teresa Díaz-Sanjuán; Teresa Muñoz-Yagüe; Erica Gómez-Izquierdo; Pablo Solís-Muñoz; José A. Solís-Herruzo The aims of this study were to determine whether fibronectin increases survival of hepatic stellate cells (HSCs) in starving...