...Zhonghu Li; Yang Tao; Xiaoya Wang; Peng Jiang; Jie Li; Minjie Peng; Xi Zhang; Kai Chen; Hui Liu; Ping Zhen; Jin Zhu; Xiangde Liu; Xiangde Liu Background/Aims: MicroRNAs (miRNAs) or exosomes have recently been shown to play vital regulatory or communication roles in cancer biology. However...

... blood of healthy controls (HCs) and patients with RA was determined by flow cytometry. MicroRNA (miRNA) expression profiles in exosomes derived from RA patients (RA-exosomes) and in those from HCs (HC-exosomes) were detected by microarray analysis, and miR-17 was measured by quantitative real-time PCR...

... regulated by the microenvironment. Fibroblasts represent a large proportion of the components in the tumor microenvironment, and they promote the development of disease. Currently, accumulating evidence suggests that exosomes can function as intercellular transport systems to relay their contents...

...) are a promising therapeutic modality for several diseases because ADSCs secret growth factors and exosomes, which modulate hostile microenvironments affected by diseases. However, the effect of exosomes on VEGF-C-dependent lymphangiogenesis and its mechanism remain unclear. Methods: ADSCs were cultured in media...

... are not fully elucidated. Given that skeletal muscle is a secretory organ, we evaluated the effects of inflammation on myogenic signals and myokine expression, and the roles of inflammatory exosomes released by myotubes in myogenic differentiation. Methods: Inflammation was induced by treatment of fully...

...Jianshu Ni; Hongchao Li; Yiwen Zhou; Baojun Gu; Yuemin Xu; Qiang Fu; Xufeng Peng; Nailong Cao; Qingchun Fu; Meng Jin; Guangxi Sun; Jihong Wang; Yinpeng Jin; Feng Liu Background/Aims: To evaluate whether local injection of exosomes derived from human adipose-derived stem cells (hADSCs) facilitates...

...Ming Song; Lu Han; Fang-fang Chen; Di Wang; Feng Wang; Lei Zhang; Zhi-hao Wang; Ming Zhong; Meng-xiong Tang; Wei Zhang Background/Aims: Adipocyte-derived exosomes (ADEs) stimulate the activation of macrophages and contribute to the development of insulin resistance. Sonic Hedgehog (Shh...

...Zeng Li; Yingjie Wang; Ke Xiao; Shuai Xiang; Zheng Li; Xisheng Weng Exosomes are a subset of small, membrane-bound extracellular vesicles that are important for communication among cells. They originate from the cell membrane during endocytic internalization, and are stable in biological fluids...

..., the role of PLAUR, particularly exosomal PLAUR in gefitinib resistance in NSCLC has not been reported. The aim of this study is to determine the relationship between PLAUR and gefitinib resistance. Methods: In this study, a tethered cationic lipoplex nanoparticle (TCLN) biochip containing molecular beacons...

...Mei Jiang; Hairong Wang; Mingming Jin; Xuelian Yang; Haifeng Ji; Yufeng Jiang; Hanwen Zhang; Feifei Wu; Guolu Wu; Xiaoyin Lai; Liying Cai; Rongguo Hu; Limin Xu; Longxuan Li Background/Aims: Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) have important...

...Tao Wu; Yichen Chen; Yantao Du; Jin Tao; Zhong Zhou; Zhuo Yang Background/Aims: MicroRNAs (miRNAs) can be used as biomarkers for cardiovascular diseases, especially for heart failure. However, there are few reports on serum exosomal miRNA biomarkers in patients with acute heart failure (AHF) due...

...Lei Zheng; Zhi Li; Wei Ling; Deming Zhu; Zhiwen Feng; Lianbao Kong Background/Aims: The present study aimed to evaluate the effects as well as the underlying mechanisms of bone marrow-derived dendritic cells (BMDCs) and exosomes produced by BMDCs (DEXs) on hepatic ischemia-reperfusion (I/R) injury...

... and to interplay with tumor cells. However, the potential functional effects of MSCs on tumor cell growth are controversial. Here, we, from the view of bone marrow MSC-derived exosomes, study the molecular mechanism of MSCs on the growth of human osteosarcoma and human gastric cancer cells. Methods: MSCs derived...

...Ming Tan; Hong-Bing Yan; Jian-Nan Li; Wen-Ke Li; Yuan-Yuan Fu; Wen Chen; Zhou Zhou Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2016 Lung cancer Exosome MiR-302b Suppress TGF-β1/ERK Cellular Physiology Cell...

.... The study hypothesized that MSC-derived exosomes play a significant role in improving microenvironment after acute myocardial infarction and aimed to investigate the paracrine effects of exosomes on angiogenesis and anti-inflammatory activity. Methods : MSCs were cultured in DMEM/F12 supplemented with 10...

...Jun Zhang; He-da Zhang; Yu-Feng Yao; Shan-Liang Zhong; Jian Hua Zhao; Jin Hai Tang Background: Currently, exosomes that act as mediators of intercellular communication are being researched extensively. Our previous studies confirmed that these exosomes contain microRNAs (miRNAs) that could alter...