...Jiuxu Bai; Xiao Xiao; Xiaoling Zhang; Hanmin Cui; Junfeng Hao; Jingming Han; Ning Cao Background/Aims: Renal tubular epithelial-mesenchymal transition (EMT) is regarded as an important factor leading to renal interstitial fibrosis. Erythropoietin (EPO) has been reported to attenuate renal fibrosis...

... are the transient receptor potential channels of canonical type (TRPC channels). The abundance of these channels in primary erythroblasts, erythroid cell lines and RBCs was associated with an increase in intracellular Ca 2+ upon stimulation with Erythropoietin (Epo). In contrast two independent studies on Epo...

... by erythropoietin. Eryptotic RBC are engulfed by macrophages and thus rapidly cleared from circulating blood. In this study, we explored whether storage of RBC influences the rate of eryptosis. Methods: Flow cytometry was employed to quantify phosphatidylserine exposing erythrocytes from annexin V binding...

... erythrocytosis is partially caused by the ability of several HCC cells to produce erythropoietin (EPO). Prolyl-4-hydroxylase 2 (PHD2) is an enzyme encoded by the gene EGLN1. The best-known function of PHD2 is to mediate the oxygen-dependent degradation of the labile α-subunit of hypoxia-inducible factor (HIF...

...Angela Risso; Annarita Ciana; Cesare Achilli; Giampaolo Minetti Background: A number of experimental investigations in vivo suggest that in humans a decrease of circulating erythrocyte number ensues whenever erythropoietin (EPO) plasma level decreases. Since the process seems to selectively...

... Lang Department of Physiology I, University of Tübingen, *contributed equally and thus share first authorship Key Words JAK2V617F Leptin Erythropoietin Cell volume regulation Chloride channels Abstract JAK2 (Janus kinase-2) is activated by cell shrinkage and may thus participate in cell volume...

...Zohreh Hosseinzadeh; Shefalee K. Bhavsar; Mentor Sopjani; Ioana Alesutan; Ambrish Saxena; Miribane Dërmaku-Sopjani; Florian Lang The Janus-activated kinase-2 JAK2 is involved in the signaling of leptin and erythropoietin receptors and mediates neuroprotective effects of the hormones. In theory...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetic retinopathy Erythropoietin Pericyte loss Acellular...

... are regulated in vivo by the ratio of AdoMet/AdoHcy, which is termed “methylation potential” (MP). To test whether high rates of erythropoietin (EPO) expression is reduced by a low MP in vivo we choosed the model of increased EPO production following carbon monoxide (CO) exposure in rats in which high...

...Mariana Callero; Gladys Pérez; Daniela Vittori; Nicolás Pregi; Alcira Nesse Background/ Aims: Since the reversible phosphorylation of tyrosyl residues is a critical event in cellular signaling pathways activated by erythropoietin (Epo), attention has been focused on protein tyrosine phosphatases...