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Keywords: Erk1/2
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Cellular Physiology and Biochemistry (2018) 51 (4): 1957–1968.
Published Online: 04 December 2018
... to investigate how simvastatin affects experimental parkinsonian models via the regulation of extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated activation of the anti-oxidant system. Methods: l-Methyl-4-phenylpyridine ion (MPP + )-treated SH-SY5Y cells and substantia nigra neurons were used...
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Cellular Physiology and Biochemistry (2018) 46 (4): 1483–1492.
Published Online: 19 April 2018
...: We cultured normal rat kidney epithelial (NRK-52E) cells, human kidney epithelial (HK-2) cells and human renal cell adenocarcinoma (769-P) cells simultaneously under normoxia and hypoxia (1% O2) for 24-72 hours. The protein levels of P-ERK1/2, ERK1/2, P-p38, p38 and eEF2K were detected by western...
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Cellular Physiology and Biochemistry (2018) 44 (6): 2467–2475.
Published Online: 18 December 2017
... to adipogenic trans-differentiation of muscle cells. ERK1/2, P38 and JNK are three major MAPK family members; their activation and regulatory functions during adipogenic trans-differentiation of myoblasts are investigated. Methods: C2C12 myoblasts were cultured and induced for adipogenic trans-differentiation...
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Cellular Physiology and Biochemistry (2017) 43 (6): 2353–2366.
Published Online: 27 October 2017
... was performed to examine the phosphorylation and protein expression of extracellular signaling-regulated kinase 1/2 (ERK1/2), signal transducer and activator of transcription 3 (Stat3), 3-phosphoinositide dependent protein kinase-1 (PDK1) and transcription factor SP1. QRT-PCR was used to examine the mRNA levels...
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Cellular Physiology and Biochemistry (2015) 37 (6): 2297–2310.
Published Online: 02 December 2015
...-ERK1/2 and Sox9, indicating that at least the ERK/PPARγ signaling pathway could be involved in the effect. Conclusions: These results constitute an experimental support to the hypothesis that power frequency MF can be one of the factors involved in the etiology of SL. Though the causal factors of LS...
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Cellular Physiology and Biochemistry (2015) 36 (2): 642–654.
Published Online: 18 May 2015
.... Furthermore, the incubation of cells with CdCl2 significantly increased the level of phosphorylated p38MAPK and significantly decreased the phosphorylation of ERK1/2 in a concentration-dependent manner. Additionally, the inhibition of the phosphorylation of p38 MAPK by SB202190 protected MG63 cells from Cd...
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Cellular Physiology and Biochemistry (2015) 35 (4): 1537–1545.
Published Online: 12 March 2015
... suggest that FFAR1/GPR40 agonists protect against lipotoxicity although the underlying mechanism remains elusive. The present study examines the role of ERK1/2 and GPR40/FFAR1 in palmitate-induced stimulation of insulin secretion and beta cell death. Methods: Insulin secretion of INS-1E cells was measured...
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Cellular Physiology and Biochemistry (2015) 35 (1): 374–385.
Published Online: 13 January 2015
... concentration ([Ca 2+ ] i ), calcium (Catsper) and potassium (Ksper) currents, and phosphorylation of extracellular signal regulated kinases 1/2 (p-ERK1/2) of the sperm were analyzed. Results: After exposure to 100 µM or more of matrine, mouse cauda epididymal sperm exhibited a significant reduction in total...
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Cellular Physiology and Biochemistry (2015) 35 (1): 246–258.
Published Online: 09 January 2015
... regulated neurite outgrowth via ERK1/2 and PI3K/Akt signaling pathway by RhoA suppression. Lentivirus and plasmid transfection of PC12 cells or PCNs were performed as previously reported [ 18 ]. Briefly, the vector of lenti-miR-133b or lenti-miR-133b-inhibitor contained a coral GFP or RFP gene...
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Cellular Physiology and Biochemistry (2014) 34 (4): 1241–1259.
Published Online: 29 September 2014
... myotube was increased during differentiation. Molecular analysis revealed that Gasp-1 overexpression resulted in increased myostatin expression related to its auto-regulation. Despite its inhibition, myostatin led to Pax7 deregulation through its non-canonical Erk1/2 signaling pathway. Consistent...
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