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Keywords: Epithelial–mesenchymal transition
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Cellular Physiology and Biochemistry (2019) 51 (6): 2547–2563.
Published Online: 11 December 2018
.... Bioinformatics studies have demonstrated the abnormal expression of CCDC43 gene in colorectal cancer (CRC). However, the role and molecular mechanism of CCDC43 in CRC remain unknown. Methods: The functional role of CCDC43 and FOXK1 in epithelial-mesenchymal transition (EMT) was determined using...
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Cellular Physiology and Biochemistry (2018) 51 (1): 11–30.
Published Online: 19 November 2018
.... Galectin Sphingosine-1-phosphate receptor 1 Epithelial-mesenchymal transition Gastric cancer Metastasis Gastric cancer is one of the most common cancers, and is the third leading cause of cancer-related deaths worldwide [ 1, 2 ]. Over the past two decades, the incidence of GC has increased...
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Cellular Physiology and Biochemistry (2018) 46 (2): 860–872.
Published Online: 29 March 2018
... and CSC- and epithelial-mesenchymal transition (EMT)-related genes, such as KLF4, Oct4, Sox2, Nanog, CD133, CD44, CD166, ALDH1, Lgr5, E-cadherin, ZO-1, Vimentin, Snail, Slug, and Twist, was examined using real-time PCR. Results: Lgr5-positive subpopulations exhibited higher capacities for colony formation...
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Cellular Physiology and Biochemistry (2018) 46 (1): 93–106.
Published Online: 20 March 2018
... the roles of miR-183 in the proliferation, epithelial-mesenchymal transition (EMT), invasion and migration of human NSCLC cells via targeting MTA1. Methods: NSCLC and adjacent normal tissues were collected from 194 patients with NSCLC. Positive expression of MTA1 protein was detected by immunohistochemistry...
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Cellular Physiology and Biochemistry (2017) 42 (5): 2078–2092.
Published Online: 11 August 2017
... and invasion, whereas miR-143-5p antisense led the opposite effects. Further elucidating the molecular mechanism inside, we found miR-143-5p exerted its inhibitory function through downregulating the expression of HIF-1α, which further reduced Twist1 and impeded epithelial-mesenchymal transition (EMT...
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Cellular Physiology and Biochemistry (2017) 42 (4): 1684–1700.
Published Online: 25 July 2017
... showed decreased SP-B regulated by the TGF-β signaling and decreased SP-B stimulated cell survival and epithelial-mesenchymal transition. Treatment with CM from irradiated cells activated sPLA 2 , enhanced protein kinase Cδ-MAPKs signaling pathway, and increased arachidonic acid production. We confirmed...
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Cellular Physiology and Biochemistry (2017) 42 (3): 1192–1201.
Published Online: 03 July 2017
... to generate TMZ-resistant colonies (the U251/TMZ and U87/TMZ cell lines). The expression levels of MALAT1 and proteins related to epithelial-mesenchymal transition (EMT) were detected by real-time PCR and western blot, respectively. After the transfection of si-MALAT1 or pcDNA-MALAT1, cell viability, mRNA...