...Manel Vera; Sergi Torramade-Moix; Susana Martin-Rodriguez; Aleix Cases; Josep M. Cruzado; Jose Rivera; Gines Escolar; Marta Palomo; Maribel Diaz-Ricart Background/Aims: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits...

..., the levels of inflammatory markers (PTX3, MCP-1, hsCRP, ICAM) and endothelial dysfunction markers (VEGF, ET-1) were significantly reduced compared to pre-treatment levels, NO was signifcantly increased post treatment. In the case control study, we found that PTX3, MCP-1, ICAM, VEGF and ET-1 levels were...

...Lei Huang; Fan Dai; Lian Tang; Xiaofeng Bao; Zhaoguo Liu; Chao Huang; Ting Zhang; Wenjuan Yao Background/Aims: This study used Rho-associated protein kinase (ROCK) isoform-selective suppression or a ROCK inhibitor to analyze the roles of ROCK1 and ROCK2 in regulating endothelial dysfunction...

... the feasibility of kefir consumption to provide benefits in cardiometabolic diseases, including hypertension, vascular endothelial dysfunction, dyslipidemia and insulin resistance. Interestingly, recent studies show that mechanisms of actions of kefir in cardiometabolic diseases include recruitment of endothelial...

... to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal...

... to renal outcome. Hazard Ratio estimates were also assessed in the Cox proportional Hazard’s model. Endothelial dysfunction is well documented as an initiating event in the development of DN [ 8 ]. Impairment of endothelial glycocalyx and loss of endothelial fenestrations [ 9, 10 ]; alteration...

... with cell structure, angiogenesis and endothelial dysfunction were investigated in distinct pools of multicellular spheroids (MCS), adherent cells (AD) and tubular structures (TS) formed after a 35-day RPM-exposure. Results: Combining morphological and molecular approaches, we found AD, MCS and TS...

... the beneficial effects of the phosphodiesterase 5 inhibitor sildenafil on this endothelial dysfunction. Methods: Adult male apoE -/- mice were treated with sildenafil (40 mg/kg/day, for 3 weeks) and compared with non-treated ApoE -/- and wild-type mice. The beneficial effects of sildenafil on vascular...

...Artur Rozentsvit; Kevin Vinokur; Sherin Samuel; Ying Li; A. Martin Gerdes; Maria Alicia Carrillo-Sepulveda Background/Aims: Elevated production of reactive oxygen species (ROS) is linked to endothelial dysfunction and is one of the key contributors to the pathogenesis of diabetic vascular...

.... Obstructive sleep apnea hypoxia syndrome/OSAHS Microparticle Endothelial dysfunction Coronary artery disease/CAD Estimated to affect 4% of men and 2% of women (over 18 million Americans) [ 1, 2 ], obstructive sleep apnea-hypopnea syndrome (OSAHS) is the result of intermittent upper airway collapse...

...Qianqian Dong; Wenjuan Xing; Feifei Su; Xiangyan Liang; Fei Tian; Feng Gao; Siwang Wang; Haifeng Zhang Aims: Obesity is a major risk for hypertension. Endothelial dysfunction contributes to increased peripheral vascular resistance and subsequent hypertension. Autophagy regulates endothelial...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Haemeoxygenase-1 Free fatty acids Endothelial dysfunction The haemeoxygenase-1...

...Fang Han; Zongguang Hui; Shuxian Zhang; Ningning Hou; Yali Wang; Xiaodong Sun Background: The induction of haemeoxygenase-1 (HO-1) exerts beneficial effects in the setting of endothelial dysfunction in obesity. High free fatty acid (FFA) levels are a common feature of obesity and are the primary...

...), an active component of the rhizome extract from Polygonum multiflorum , exhibits significant anti-atherosclerotic activity. However, the protective effects of TSG against oxLDL-induced endothelial dysfunction have not been clarified. We investigated the cytoprotective effects of TSG in human umbilical vein...