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Keywords: Dichloroacetate
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Subject Area:
Further Areas
Marena Rebekka Niewisch, Zyrafete Kuçi, Hartwig Wolburg, Mirjam Sautter, Lea Krampen, Beate Deubzer, Rupert Handgretinger, Gernot Bruchelt
Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 29 (3-4): 373–380.
Published Online: 03 April 2012
... (Warburg effect). Dichloroacetate (DCA) is a drug which is able to shift pyruvate metabolism from lactate to acetyl-CoA (tricarboxylic acid cycle) by indirect activation of pyruvate dehydrogenase (PDH). This can subsequently lead to an increased flow of oxygen in the respiratory chain, associated...
