...Xiang Ren; Ni-na Wang; Hui Qi; Yuan-yuan Qiu; Cheng-hong Zhang; Emily Brown; Hui Kong; Li Kong Background/Aims: Diabetic retinopathy (DR) is one of the most serious complications of diabetes and is the leading cause of adult blindness in developed countries. Advanced glycation end products (AGEs...

... (RVECs) under high glucose conditions and tissues altered by diabetic retinopathy (DR). In this study, we focused on the correlations between O-GlcNAcylation and STAT3 phosphorylation, and their potential effects with regards to DR. Methods: Expression of O-GlcNAcylation and STAT3 were detected in DR...

...Xianliang Gu; Xi Yu; Chen Zhao; Ping Duan; Tongtao Zhao; Yong Liu; Shiying Li; Zhi Yang; Yunyan Li; Cheng Qian; Zhengqin Yin; Yi Wang Background/Aims: The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) are a promising treatment option for diabetes and its...

...Jing Xu; Lin-Jiang Chen; Jian Yu; Han-Jing Wang; Fan Zhang; Qiong Liu; Jing Wu Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic...

...Ying Su; Jingli Chen; Zengxiang Dong; Yan Zhang; Ruishuang Ma; Junjie Kou; Feng Wang; Jialan Shi Background/Aims: The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. The purpose of this study was to test phosphatidylserine (PS) exposure...

... tight junctions. α-MSH acts predominantly on MC4R to antagonize hyperpermeability in retinal microvessel endothelial cells. Diabetic macular edema (DME) is one of the severe complications of diabetic retinopathy (DR), and is becoming the leading cause of vision loss in DR [ 1 ]. The DME is mainly...

...Ao-Wang Qiu; Qing-Huai Liu; Jun-Ling Wang Background/Aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune...

...Jie Wei; Hua Jiang; Hongrui Gao; Guangjie Wang Background/Aims: Prior studies demonstrate that hypoxia inducible factor subtype 1α (HIF-1α) in retinal tissues is involved in development of diabetic retinopathy (DR). In this report, we particularly examined the role played by mammalian target...

...Jun Li; Peipei Wang; Jia Ying; Zhen Chen; Songping Yu Background: Curcumin possesses many pharmacological properties including anti-inflammatory effects. Although prior studies indicate that curcumin has beneficial effects for diabetic retinopathy, the mechanism of action is not known. To address...

...Rong-Mei Zhou; Yi Shen; Jin Yao; Hong Yang; Kun Shan; Xiu-Miao Li; Qin Jiang; Biao Yan Background/Aims: Retinal neurodegeneration is an early event in the pathological process of diabetic retinopathy (DR). Retinal ganglion cell (RGC) injury is an important pathological feature during...

... Diabetic retinopathy Photoreceptor degeneration Cellular homeostasis requires a constant balance between biosynthetic and catabolic processes. Eukaryotic cells possess two major mechanisms for large-scale degradation, including proteasome and autophagy [ 1 ]. Autophagy is an evolutionarily...

...Frederick Pfister; Eva Riedl; Qian Wang; Franziska vom Hagen; Martina Deinzer; Martin C. Harmsen; Grietje Molema; Benito Yard; Yuxi Feng; Hans-Peter Hammes Backgrounds/Aims: Pericyte loss, vasoregression and neuroglial activation are characteristic changes in incipient diabetic retinopathy...

...Qian Wang; Stefan Gorbey; Frederick Pfister; Simone Höger; Andrea Dorn-Beineke; Katja Krügel; Elena Berrone; Liang Wu; Thomas Korff; Jihong Lin; Stefanie Busch; Andreas Reichenbach; Yuxi Feng; Hans-Peter Hammes Background/Aims: Diabetic retinopathy is characterized by pericyte loss...

...Yuxi Feng; Yumei Wang; Frederick Pfister; Jan-Luuk Hillebrands; Urban Deutsch; Hans-Peter Hammes Background/Aims: Proliferative diabetic retinopathy is characterized by the formation of retinal neovascularization. Angiopoietin-2 (Ang-2) and matrix metalloproteinase (MMP) play a critical role...