...Hengyu Tian; Junbo Yang; Zhuochao Xie; Jialin Liu Background/Aims: Diabetic nephropathy is a common complication of diabetes. This study explored the renal protective effect and possible mechanism of gliquidone in mice with diabetic nephropathy. Methods: Animal model of diabetic nephropathy...

... the upstream trigger and the downstream effector driving diabetic nephropathy via modulating mitochondrial homeostasis. Methods: A diabetic nephropathy model was generated in wild-type (WT) mice and MAP Kinase phosphatase 1 transgenic (MKP1-TG) mice using STZ injection. Cell experiments were conducted via high...

...Yajuan Zhang; Yan Sun; Rui Peng; Handeng Liu; Weihao He; Luyu Zhang; Huimin Peng; Zheng Zhang Background/Aims: Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common complication of diabetes. However, the initiating molecular events triggering DN are unknown...

...Suyu Wang; Xin Chen; Min Wang; Di Yao; Tianyu Chen; Qin Yan; Weiping Lu Background/Aims: Our previous studies demonstrated that a novel long non-coding RNA, CYP4B1-PS1-001, was significantly downregulated in early diabetic nephropathy in vivo and in vitro , and CYP4B1-PS1-001 overexpression could...

...Deng Yunlei; Fan Qiuling; Wang Xu; Zhao Qianwen; Cao Xu; Xu Li; Wang Lining Background/Aims: Diabetic nephropathy is the one of the most serious microvascular complications of diabetes mellitus, and “metabolic memory” plays a vital role in the development of diabetic complications. To investigate...

...Ying Fan; Yang Fei; Li Zheng; Jiemin Wang; Wenzhen Xiao; Jiejun Wen; Yanping Xu; Yiyun Wang; Li He; Jian Guan; Jia Wei; John Cijiang He; Niansong Wang Background/Aims: Glomerular endothelial cell injury plays a crucial role in the development of diabetic nephropathy (DN). CD146, an endothelial...

...Jianxun Feng; Chang Lu; Qin Dai; Junqin Sheng; Min Xu Background/Aims: Amniotic fluid stem cells (AFSCs) transplantation is a promising therapeutic strategy for diabetic nephropathy. Sirtuin3 (SIRT3) is a novel mitochondrial protective factor. In the present study, we aimed to investigate whether...

...Sungjin Park; SeongRyeol Moon; Kiyoung Lee; Ie Byung Park; Dae Ho Lee; Seungyoon Nam Background/Aims: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical...

..., such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and in vivo . Methods: MG-induced cell toxicity was characterized by MTT and MG-H1-formation, scavenging abilities...

... of the proximal renal nephron. Methods: Biopsy material from patients with and without diabetic nephropathy was stained for connexin-26 (CX26) and connexin-43 (CX43). Changes in expression were corroborated by immunoblot analysis in human primary proximal tubule epithelial cells (hPTECs) and model epithelial...

... patients with moderate renal impairment. As its effect on kidney function is discrepant and complicated, the aim of this study is to determine the effect of dapagliflozin on the progression of diabetic nephropathy and related mechanisms. Methods: Twelve-week-old male C 57 BL/6 wild-type and db/db mice were...

...Rong-Mei Wang; Zhi-Bin Wang; Yue Wang; Wei-Ye Liu; Ya Li; Ling-Chang Tong; Su Zhang; Ding-Feng Su; Yong-Bing Cao; Ling Li; Li-Chao Zhang Background/Aims: Podocyte injury, especially podocyte apoptosis, plays a major role in early-stage diabetic nephropathy (DN). Swiprosin-1, also known as EF hand...

...Biyu Hou; Guifen Qiang; Yuerong Zhao; Xiuying Yang; Xi Chen; Yu Yan; Xiaobo Wang; Chenge Liu; Li Zhang; Guanhua Du Background/Aims: Glomerular endothelium dysfunction leads to the progression of renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN). Advanced...

...Suxia Yang; Junwei Zhang; Shiying Wang; Jun Shi; Xinxin Zhao Background/Aims: Angiopoietin-like protein 2 (ANGPTL2) was reported to be implicated in the pathogenesis of inflammatory disease. Its role in diabetic nephropathy (DN) remained illdefined. Methods: qRT-PCR and western blot analysis were...

...Jia Guo; Congqun Lu; Fangxing Zhang; Haixia Yu; Mengwen Zhou; Meixia He; Chunyan Wang; Zhanzheng Zhao; Zhangsuo Liu Background: Diabetic nephropathy (DN) is a major cause of end-stage renal disease and proteinuria is one of the most prominent clinical manifestations. The expression of Vitamin D...

...Haiyan Han; Aili Cao; Li Wang; Hengjiang Guo; Yingjun Zang; Zezheng Li; Xuemei Zhang; Wen Peng Background/Aims: Huangqi Decoction (HQD) has been traditionally used to treat diabetes mellitus in China. The present study was carried out to assess the protective effect of HQD on diabetic nephropathy...

...Sutong Li; Xiaoxia Liu; Jie Lei; Junle Yang; Puxun Tian; Yi Gao Background/Aims: Diabetic nephropathy (DN) is a microangiopathic disease characterized by excessive urinary albumin excretion, which occurs in 30% of patients with diabetes mellitus. It is the second leading cause of end-stage renal...

...Qing Li; Ji Li; Hua Shao; Xiao-Xue Li; Feng Yu; Ming Xu Background/Aims: Our previous studies have indicated that a novel endothelin receptor antagonist CPU0213 effectively normalized renal function in diabetic nephropathy. However, the molecular mechanisms mediating the nephroprotective role...

... Diabetic nephropathy (DN), as one of the most serious complications of diabetes mellitus, is the main cause of end-stage renal failure (ESRD). However, effective treatment for reducing proteinuria and delaying progression of renal tubulointerstitial fibrosis is lack. Therefore, it is imperative...

...Xi Li; Ling Wang; Xingxin Gao; Guoping Li; Honghua Cao; Dezhi Song; Shuangqi Cai; Tao Liang; Bo Zhang; Gang Du Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established...