...Jung-Hwan Lew; Koji Naruishi; Yukari Kajiura; Yasufumi Nishikawa; Takahisa Ikuta; Jun-ichi Kido; Toshihiko Nagata Background/Aims: Diabetic patients are susceptible to severe periodontitis, but the precise mechanism is not fully understood. Aim of this study was to explore the biological...

...Xing-Rong An; Xin Li; Wei Wei; Xiao-Xue Li; Ming Xu Background/Aims: The phenotype switching of vascular smooth muscle cells (VSMCs) was associated with the onset or progression of the atherogenic process in type 2 diabetes mellitus (T2DM). Alprostadil (Prostaglandin E1, PGE1) as a bioactive drug...

...Xiaoming Zhang; Ke Meng; Yujie Pu; Chao Wang; Yingying Chen; Linlin Wang Background/Aims: Hyperglycemia is an important risk factor for the most severe cardiovascular diseases in patients with diabetes. It has been demonstrated that cardiac stem cells (CSCs) play a pivotal role in the maintenance...

... potential vanilloid 1 (TRPV1) in diabetic mouse cardiac function. Methods : Intragastric QLQX was administered for 5 weeks after streptozotocin (STZ) treatment. Additionally, Intraperitoneal injections of angiotensin II (Ang II) or intragastric losartan (Los) were administered to assess the activities...

... ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized...

...Mohammed Al Za’abi; Suhail Al Salam; Yousuf Al Suleimani; Priyadarsini Manoj; Abderrahim Nemmar; Badreldin H. Ali Background/Aims: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non – diabetic rats with adenine...

... cardiac fiber was used to assess the effect of Pim1-mediated phosphorylation on cardiac myofilament activity. Lastly, the functional significance of Pim1-mediated cTnI in heart disease was determined in diabetic mice. Results: We found that Pim-1 specifically interacts with cTnI in cardiomyocytes...

... cardioprotection against myocardial ischemia/reperfusion (I/R) injury in diabetes is unknown. Methods: Eight-week streptozotocin-induced diabetic and non-diabetic Sprague-Dawley rats were subjected to I/R without or with rNLIP. In vitro , H9C2 cells were cultured with high glucose (HG) and subjected to hypoxia/re...

...Artur Rozentsvit; Kevin Vinokur; Sherin Samuel; Ying Li; A. Martin Gerdes; Maria Alicia Carrillo-Sepulveda Background/Aims: Elevated production of reactive oxygen species (ROS) is linked to endothelial dysfunction and is one of the key contributors to the pathogenesis of diabetic vascular...

...Fan Deng; Shuang Wang; Liangqing Zhang; Xiang Xie; Shuyun Cai; Haobo Li; Gui-ling Xie; Hui-Lai Miao; Changmin Yang; Xin Liu; Zhengyuan Xia Background/Aims: Hearts from diabetic subjects are susceptible to myocardial ischemia reperfusion (I/R) injury. Propofol has been shown to protect against...

...Ting Yu; Yun Wang; Dong Qian; Xiaomeng Sun; Yurong Tang; Xiaoxue Shen; Lin Lin Background/Aims: Excessive production of advanced glycation end products (AGEs) has been implicated in diabetes-related complications. This study aimed to investigate the mechanism by which AGEs potentially contribute...

...Fernando H. G. Tessaro; Thais S. Ayala; Eduardo L. Nolasco; Leonardo M. Bella; Joilson O. Martins Background/Aims: Diabetic subjects are more susceptible to infections, which is partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release...

...Kai Dong; Pengjie Hao; Sheng Xu; Shutai Liu; Wenjuan Zhou; Xilong Yue; Xiaohui Rausch-FAN; Zhonghao Liu Background/Aims: Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally...

... group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic...

..., and blocking of Ang II is more important than inhibition of TGF-β in non-penile tissue fibrosis. However, the role of Ang II in corporal fbrosis and CVOD in a diabetic condition has not been investigated. Methods: Diabetic rats were treated with sildenafil or losartan (an Ang II antagonist) alone...

...; Paulo Cezar de Freitas Mathias Background/Aims: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms...

... function evoked by CCl 4 to a greater degree in diabetic animals. Methods: ELISA and Western Blot analysis were used to examine PAR2 signaling pathway in diabetic CCl 4 -rats and non-diabetic CCl 4 -rats. Results: AGS inhibited the protein expression of PAR2 and its downstream pathway PKA and PKCɛ in CCl 4...

... may play a regulatory role on insulin secretion, immune modulation and insulin resistance. Given that diabetes and insulin resistance are attributable to elevated inflammatory tone, we investigated the role of CB 2 receptor on glucose tolerance and insulin sensitivity in high-fat diet (HFD...

... of ivabradine (IBD) on cardiac function and plasma NE and BNP-45 after chronic ischemic heart failure (CHF) in non-diabetic rats and diabetic rats. We further determined if sympathetic NE uptake-1 (a major pathway to metabolize NE) mechanism is responsible for the role played by IBD. Methods: We ligated rat's...

... in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect...