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Jung-Hwan Lew, Koji Naruishi, Yukari Kajiura, Yasufumi Nishikawa, Takahisa Ikuta, Jun-ichi Kido, Toshihiko Nagata
Cellular Physiology and Biochemistry (2018) 50 (3): 973–986.
Published Online: 24 October 2018
...Jung-Hwan Lew; Koji Naruishi; Yukari Kajiura; Yasufumi Nishikawa; Takahisa Ikuta; Jun-ichi Kido; Toshihiko Nagata Background/Aims: Diabetic patients are susceptible to severe periodontitis, but the precise mechanism is not fully understood. Aim of this study was to explore the biological...
Cellular Physiology and Biochemistry (2018) 50 (2): 745–756.
Published Online: 11 October 2018
...Xing-Rong An; Xin Li; Wei Wei; Xiao-Xue Li; Ming Xu Background/Aims: The phenotype switching of vascular smooth muscle cells (VSMCs) was associated with the onset or progression of the atherogenic process in type 2 diabetes mellitus (T2DM). Alprostadil (Prostaglandin E1, PGE1) as a bioactive drug...
Cellular Physiology and Biochemistry (2018) 49 (6): 2254–2263.
Published Online: 26 September 2018
...Xiaoming Zhang; Ke Meng; Yujie Pu; Chao Wang; Yingying Chen; Linlin Wang Background/Aims: Hyperglycemia is an important risk factor for the most severe cardiovascular diseases in patients with diabetes. It has been demonstrated that cardiac stem cells (CSCs) play a pivotal role in the maintenance...
Jing Tong, Yan Lai, Yi-An Yao, Xue-Jun Wang, Yu-Shuang Shi, Han-Jin Hou, Jian-Yun Gu, Fei Chen, Xue-Bo Liu
Cellular Physiology and Biochemistry (2018) 47 (4): 1365–1376.
Published Online: 19 June 2018
... potential vanilloid 1 (TRPV1) in diabetic mouse cardiac function. Methods : Intragastric QLQX was administered for 5 weeks after streptozotocin (STZ) treatment. Additionally, Intraperitoneal injections of angiotensin II (Ang II) or intragastric losartan (Los) were administered to assess the activities...
Ramoji Kosuru, Yin Cai, Vidya Kandula, Dan Yan, Chunyan Wang, Hong Zheng, Yalan Li, Michael G. Irwin, Sanjay Singh, Zhengyuan Xia
Cellular Physiology and Biochemistry (2018) 46 (4): 1381–1397.
Published Online: 18 April 2018
... ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized...
Mohammed Al Za’abi, Suhail Al Salam, Yousuf Al Suleimani, Priyadarsini Manoj, Abderrahim Nemmar, Badreldin H. Ali
Cellular Physiology and Biochemistry (2018) 45 (6): 2293–2304.
Published Online: 13 March 2018
...Mohammed Al Za’abi; Suhail Al Salam; Yousuf Al Suleimani; Priyadarsini Manoj; Abderrahim Nemmar; Badreldin H. Ali Background/Aims: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non – diabetic rats with adenine...
Cellular Physiology and Biochemistry (2018) 45 (6): 2174–2186.
Published Online: 10 March 2018
... cardiac fiber was used to assess the effect of Pim1-mediated phosphorylation on cardiac myofilament activity. Lastly, the functional significance of Pim1-mediated cTnI in heart disease was determined in diabetic mice. Results: We found that Pim-1 specifically interacts with cTnI in cardiomyocytes...
Chunyan Wang, Haobo Li, Sheng Wang, Xiaowen Mao, Dan Yan, Stanley S. Wong, Zhengyuan Xia, Michael G. Irwin
Cellular Physiology and Biochemistry (2018) 45 (5): 2107–2121.
Published Online: 07 March 2018
... cardioprotection against myocardial ischemia/reperfusion (I/R) injury in diabetes is unknown. Methods: Eight-week streptozotocin-induced diabetic and non-diabetic Sprague-Dawley rats were subjected to I/R without or with rNLIP. In vitro , H9C2 cells were cultured with high glucose (HG) and subjected to hypoxia/re...
Artur Rozentsvit, Kevin Vinokur, Sherin Samuel, Ying Li, A. Martin Gerdes, Maria Alicia Carrillo-Sepulveda
Cellular Physiology and Biochemistry (2017) 44 (3): 1174–1187.
Published Online: 28 November 2017
...Artur Rozentsvit; Kevin Vinokur; Sherin Samuel; Ying Li; A. Martin Gerdes; Maria Alicia Carrillo-Sepulveda Background/Aims: Elevated production of reactive oxygen species (ROS) is linked to endothelial dysfunction and is one of the key contributors to the pathogenesis of diabetic vascular...
Fan Deng, Shuang Wang, Liangqing Zhang, Xiang Xie, Shuyun Cai, Haobo Li, Gui-ling Xie, Hui-Lai Miao, Changmin Yang, Xin Liu, Zhengyuan Xia
Cellular Physiology and Biochemistry (2018) 44 (1): 279–292.
Published Online: 09 November 2017
...Fan Deng; Shuang Wang; Liangqing Zhang; Xiang Xie; Shuyun Cai; Haobo Li; Gui-ling Xie; Hui-Lai Miao; Changmin Yang; Xin Liu; Zhengyuan Xia Background/Aims: Hearts from diabetic subjects are susceptible to myocardial ischemia reperfusion (I/R) injury. Propofol has been shown to protect against...
Cellular Physiology and Biochemistry (2017) 43 (4): 1571–1587.
Published Online: 16 October 2017
...Ting Yu; Yun Wang; Dong Qian; Xiaomeng Sun; Yurong Tang; Xiaoxue Shen; Lin Lin Background/Aims: Excessive production of advanced glycation end products (AGEs) has been implicated in diabetes-related complications. This study aimed to investigate the mechanism by which AGEs potentially contribute...
Cellular Physiology and Biochemistry (2017) 42 (5): 2093–2104.
Published Online: 15 August 2017
...Fernando H. G. Tessaro; Thais S. Ayala; Eduardo L. Nolasco; Leonardo M. Bella; Joilson O. Martins Background/Aims: Diabetic subjects are more susceptible to infections, which is partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release...
Kai Dong, Pengjie Hao, Sheng Xu, Shutai Liu, Wenjuan Zhou, Xilong Yue, Xiaohui Rausch-FAN, Zhonghao Liu
Cellular Physiology and Biochemistry (2017) 42 (5): 1897–1906.
Published Online: 03 August 2017
...Kai Dong; Pengjie Hao; Sheng Xu; Shutai Liu; Wenjuan Zhou; Xilong Yue; Xiaohui Rausch-FAN; Zhonghao Liu Background/Aims: Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally...
Rodrigo Mello Gomes, Luis Fernando de Paulo, Cynthia Priscilla do Nascimento Bonato Panizzon, Camila Quaglio Neves, Bruna Colombo Cordeiro, Jacqueline Nelisis Zanoni, Flávio Andrade Francisco, Silvano Piovan, Paulo Cezar de Freitas Mathias, Renata Longhini, João Carlos Palazzo de Mello, Júlio Cezar de Oliveira, Gustavo Rodrigues Pedrino, Angela Adamski da Silva Reis, Alessandra Lourenço Cecchini, Maria Raquel Marçal Natali
Cellular Physiology and Biochemistry (2017) 42 (3): 1087–1097.
Published Online: 29 June 2017
... group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic...
Cellular Physiology and Biochemistry (2017) 42 (1): 333–345.
Published Online: 25 May 2017
..., and blocking of Ang II is more important than inhibition of TGF-β in non-penile tissue fibrosis. However, the role of Ang II in corporal fbrosis and CVOD in a diabetic condition has not been investigated. Methods: Diabetic rats were treated with sildenafil or losartan (an Ang II antagonist) alone...
Claudinéia Conationi da Silva Franco, Carina Previate, Kátia Gama de Barros Machado, Silvano Piovan, Rosiane Aparecida Miranda, Kelly Valério Prates, Veridiana Mota Moreira, Júlio Cezar de Oliveira, Luiz Felipe Barella, Rodrigo Mello Gomes, Flávio Andrade Francisco, Isabela Peixoto Martins, Audrei Pavanello, Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Ananda Malta, Aline Amenencia de Souza, Vander Silva Alves, Sandra da Silva Silveira, Maria Raquel Marçal Natali, Jean Carlos Fernando Besson, Hely de Morais, Helenir Medri de Souza, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Paulo Cezar de Freitas Mathias
Cellular Physiology and Biochemistry (2017) 42 (1): 81–90.
Published Online: 11 May 2017
...; Paulo Cezar de Freitas Mathias Background/Aims: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms...
Cellular Physiology and Biochemistry (2017) 41 (3): 1156–1166.
Published Online: 28 February 2017
... function evoked by CCl 4 to a greater degree in diabetic animals. Methods: ELISA and Western Blot analysis were used to examine PAR2 signaling pathway in diabetic CCl 4 -rats and non-diabetic CCl 4 -rats. Results: AGS inhibited the protein expression of PAR2 and its downstream pathway PKA and PKCɛ in CCl 4...
Subject Area:Topic Article Package: Diabetes , Topic Article Package: Diabetes 2017 , Further Areas
Xiuyuan Zhang, Shan Gao, Jinfeng Niu, Pan Li, Juan Deng, Shixin Xu, Zhihong Wang, Weiwei Wang, Deling Kong, Chen Li
Cellular Physiology and Biochemistry (2016) 40 (5): 1175–1185.
Published Online: 14 December 2016
... may play a regulatory role on insulin secretion, immune modulation and insulin resistance. Given that diabetes and insulin resistance are attributable to elevated inflammatory tone, we investigated the role of CB 2 receptor on glucose tolerance and insulin sensitivity in high-fat diet (HFD...
Cellular Physiology and Biochemistry (2016) 39 (5): 2055–2064.
Published Online: 31 October 2016
... of ivabradine (IBD) on cardiac function and plasma NE and BNP-45 after chronic ischemic heart failure (CHF) in non-diabetic rats and diabetic rats. We further determined if sympathetic NE uptake-1 (a major pathway to metabolize NE) mechanism is responsible for the role played by IBD. Methods: We ligated rat's...
Subject Area:Topic Article Package: Diabetes 2016 , Topic Article Package: Diabetes , Further Areas
Gengyin Wang, Hui Fang, Yanfeng Zhen, Gang Xu, Jinli Tian, Yazhong Zhang, Dandan Zhang, Guyue Zhang, Jing Xu, Zhiyue Zhang, Mingyue Qiu, Yijia Ma, Hongrui Zhang, Xinxin Zhang
Cellular Physiology and Biochemistry (2016) 39 (3): 901–907.
Published Online: 09 August 2016
... in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect...