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Keywords: Deubiquitinase
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Cellular Physiology and Biochemistry (2018) 45 (6): 2421–2430.
Published Online: 15 March 2018
... responses that ultimately lead to heart failure. Auranofin (Aur) has been used for treating rheumatic arthritis for several decades. Aur is a 19S proteasome-associated deubiquitinase inhibitor, and inhibition of the proteasome is speculated to reverse cardiac hypertrophy. However, the role...