... (GlcNAc), a type of monosaccharide derived from chitosan, combined with TRAIL was evaluated in vitro and in vivo . Thirty NSCLC clinical samples were used to detect the expression of death receptor (DR) 4 and 5. After GlcNAc and TRAIL co-treatment, DR expression was determined by real-time PCR and western...

... was observed along with formation of death-inducing signaling complex between TNF-R1 and TRADD. COR-D suppressed PDK1 and AKT with activation of MAP kinase family members ERK1/2, JNK1/2 and p38. Thus it induced apoptosis by activating mitochondrial and death receptor pathways and suppressing AKT/PKB rather...

... quantitative differences in gene expression. Functional analysis showed overrepresentation of genes associated with cell death in presence of CsA. This correlated with increased mRNA expression of genes associated with the death receptor pathway and detection of TNFΑ in culture medium of cells treated with CsA...