...Yan Gao; Chen Liang; Jianhai Zhang; Junjie Ma; Jinming Wang; Ruiyan Niu; Chiranjeevi Tikka; Yewei Wang; Jundong Wang Background/Aims: We investigated the combined toxic effect of sodium fluoride (NaF) and sulfur dioxide (SO 2 ) on kidney morphological changes and DNA damage in male Wistar rats...

...Guangming Wang; Fangce Wang; Jie Ren; Yue Qiu; Wenjun Zhang; Shane Gao; Danjing Yang; Zhigang Wang; Aibin Liang; Zhengliang Gao; Jun Xu Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative...

... and studies have shown that exposure to RF-EMFs can induce DNA damage and autophagy. However, there are no related reports on the role of autophagy in DNA damage in spermatocytes, especially after exposure to RF-EMFs. The aim of the present study was to determine the mechanism and role of autophagy induced...

... differentiation was evaluated by ALP and ARS staining. DCFH-DA staining and γ-H2A.X immunostaining were used to measure intracellular levels of ROS production and DNA damage. Results: Both cell counting and EdU staining assays showed that cell proliferation of BMSCs was significantly reduced upon blue LED...

..., renal DNA damage was significantly potentiated in adenine+DEP compared with either adenine+saline or DEP. Similarly, systolic blood pressure was increased in adenine+DEP versus adenine+saline or DEP, and in DEP versus saline. Histological evaluation revealed more collagen deposition, higher number...

... and DNA damage and their association with impairment of lung function. Methods: Mice were nose-only exposed to mainstream WPS (30 min/day; 5 days/week for 6 consecutive months). Control mice were exposed using the same protocol to atmospheric air only. At the end of the exposure period, several...

... patients fail responding to radiotherapy because GBM cells remain highly resistant to radiation. Radiotherapy-induced DNA damage response may correlate with therapeutic resistance. Methods: Ionizing radiation (IR) was used to induce DNA damage. Cell proliferation and migration were detected by wound...

... factor (AIF) from mitochondria to nucleus was visualized by confocal laser scanning microscopy; DNA damage was detected by single cell gel electrophoresis; Cell cycle distribution was analyzed by DNA content with flow cytometry; Cell cycle associated proteins were detected by western blotting. Results...

... are not fully understood. The aim of this study was to find relationship between diabetes-related DNA damage in the rat liver and activities of prosurvival signaling pathways. Methods: Effect of diabetes was analyzed two (development stage) and eight weeks (stable diabetes) after single intraperitoneal...

... mutated). Although it is well accepted that ATM is a pivotal mediator in genotoxic stress, it is unknown whether ATM transcription is regulated during the molecular response to DNA damage. Here we investigate ATM transcription regulation in human prostate tumor PC3 cell line. We have found...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cell volume regulation Glutathione TauT activity Programmed cell death DNA damage Cisplatin accumulation Cellular Physiology...

...Alireza Shirpoor; Syranush Minassian; Siamak Salami; Mohammad Hassan Khadem-Ansari; Marine Yeghiazaryan Background / aims: The present study was initiated in order to investigate the protective effects of α-lipoic acid upon ethanol-induced DNA damage, lipid peroxidation and protein oxidation...

... to H 2 O 2 induced cell cycle arrest at 24h and increased SA-β-gal activity at 48h. This pathway likely plays an important role in the acceleration of cellular senescence by oxidative stress. SIRT1 p53 H 2 O 2 DNA damage Cellular senescence NAD + Cellular Physiology and Biochemistry...