... ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of CUL4A expression in colorectal cancer is unknown; in particular, the prognostic value of CUL4A combined with TP53 expression has not been explored. Methods: We analyzed the expression of CUL4A in both public...

...Dongzhi Hu; Yang Zhan; Kegan Zhu; Ming Bai; Jiayi Han; Yiran Si; Haiyang Zhang; Dalu Kong Background/Aims: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths worldwide. Thus, methods for early diagnosis of CRC are urgently...

.... Bioinformatics studies have demonstrated the abnormal expression of CCDC43 gene in colorectal cancer (CRC). However, the role and molecular mechanism of CCDC43 in CRC remain unknown. Methods: The functional role of CCDC43 and FOXK1 in epithelial-mesenchymal transition (EMT) was determined using...

...Yang Feng; Yaqi Li; Weixing Dai; Shaobo Mo; Qingguo Li; Sanjun Cai Background/Aims: Alpha-fetoprotein-producing colorectal cancer (AFPP-CRC) is quite rarely seen. This study aimed to elucidate the clinicopathologic characteristics and prognostic factors of AFPP-CRC. Methods: Among 5,051 colorectal...

...Yongqiang Hua; Yaodong Zhu; Jijie Zhang; Zhenfeng Zhu; Zhouyu Ning; Hao Chen; Luming Liu; Zhen Chen; Zhiqiang Meng Background/Aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug...

...Xiangyu Zhu; Si-ping Ma; Dongxiang Yang; Yanlong Liu; Yong-peng Wang; Tao Lin; Yan-xi Li; Shi-hua Yang; Wan-chuan Zhang; Xin-ling Wang Background/Aims: Deregulation of microRNAs (miRNAs) has been associated with a variety of cancers, including colorectal cancer (CRC). Here, we investigated...

... or modified Glasgow Prognostic Score (GPS/mGPS) is a novel inflammatory indicator which consists of CRP and albumin. Here, we performed a meta-analysis to evaluate the prognostic value of the GPS/ mGPS in patients with colorectal cancer (CRC) and to assess its consistency in different CRC therapies. Methods...

...Jian Zhao; Jian Xu; An-quan Shang; Rui Zhang Background/Aims: Colorectal cancer (CRC) is one of the most common malignant tumor with high migration and invasion capacity. Long non-coding RNAs (lncRNAs) have been identified to influence multiple cancers progression through competitively binding...

...Wenqi Li; Huining Li; Ruiqi Liu; Xinxin Yang; Yuhui Gao; Yangyang Niu; Jiashi Geng; Yingwei Xue; Xiaoming Jin; Qi You; Jingshu Geng; Hongxue Meng Background/Aims: Colorectal cancer (CRC) is mainly caused by chromosomal instability (CIN) and microsatellite instability (MSI). The RAS and RAF genes...

...Li Liang; Jiawen Tian; Yiyi Yu; Zhiming Wang; Ke Peng; Ruiqi Liu; Yan Wang; Xiaojing Xu; Hong Li; Rongyuan Zhuang; Yuehong Cui; Chouwen Zhu; Tianshu Liu Background/Aims: Non-radical primary tumour resection (PTR) of asymptomatic metastatic colorectal cancer (mCRC) can prolong survival time of some...

...Xiaolin Hou; Xuelai He; Kang Wang; Nengyi Hou; Junwen Fu; Guiqing Jia; Xiaofei Zuo; Haibo Xiong; Minghui Pang Background/Aims: Colorectal cancer (CRC) is one of leading cancers in both incidence and mortality rate. The 5-year survival rate varies considerably depending on the pathological stage...

...Zhi Chen; Ruizhi Hou; Shuohui Gao; Defeng Song; Ye Feng Background/Aims: The present study was aimed at examining Ezrin expression in human colorectal cancer (CRC) tissues and elucidating the influence of baicalein on the proliferation of HCT116 cells. Methods: The expression of Ezrin...

...Kaiming Wu; Jun Ma; Yanfeng Zhan; Kuanzhi Liu; Ziyin Ye; Jianhui Chen; Kaiwu Xu; Hongli Huang; Yulong He Background/Aims: Colon cancer, also known as colorectal cancer (CRC), is one of the most common malignant tumors globally. Although significant advances have been made for developing novel...

... colorectal cancer cell proliferation, cell cycle progression and apoptosis in vitro . The xenograft tumor formation assay in nude mice was established to evaluate tumor growth in vivo . RNA immunopreciptation (RIP) analysis was performed to examine whether SNHG6 could bind to EZH2 (enhancer of zeste 2...

.... The present study aimed to investigate the SRGN gene expression and its regulation as downstream signaling of hypoxia-inducible transcription factor 1 alpha ( HIF-1α ) in colorectal cancer (CRC) cells and tissues. Methods: The expression of SRGN was analyzed in CRC specimens for its correlation...

...Lin Shui; Yu-Shen Wu; Huapeng Lin; Pixian Shui; Qin Sun; Xiaopin Chen Background/Aims: Conversion therapy can convert unresectable metastatic colorectal cancer (mCRC) into resectable. However, the optimal conversion regimen was not yet defined. This meta-analysis aimed to compare the efficacy...

...Luyao Zhang; Liang He; Hua Zhang; Yan Chen Background/Aims: Platinum-based chemotherapy is one of the most important strategies for treatment of colorectal cancer. To improve the therapeutic efficiency, adjuvant drugs were sought to sensitize colorectal cancer cells to platinum-based agents...

... stages of colorectal cancer with negative lymph node (LN) metastasis. In contrast to the established prognostic factors such as T stage and grading, the histological subtype is not thought to contribute to the therapeutic outcome, although different subtypes can potentially represent different entities...

...Shu Gong; Dongsheng Xu; Jialin Zhu; Fangdong Zou; Rui Peng Background/Aims: Mutations in the Ras/Raf/MEK/ERK pathway are detected in 50% of colorectal cancer cases and play a crucial role in cancer development and progression. Cobimetinib is a MEK inhibitor approved for the treatment of advanced...

...Xiaoting Huang; Li Xiang; Yueqiao Li; Yingying Zhao; Huiqiong Zhu; Yizhi Xiao; Mengwei Liu; Xiaosheng Wu; Zhiqing Wang; Ping Jiang; Haitao Qing; Qiang Zhang; Guangnan Liu; Wenjing Zhang; Aimin Li; Ye Chen; Side Liu; Jide Wang Background/Aims: Metastasis is the primary cause of colorectal cancer...