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Keywords: Cofilin
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Journal Articles

YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways

Open Access
Subject Area:
Further Areas
Haijun Li, Fucheng He, Xin Zhao, Yuan Zhang, Xi Chu, Chunlan Hua, Yunhui Qu, Yu Duan, Liang Ming
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2018) 44 (5): 2073–2089.
https://doi.org/10.1159/000485946
Published Online: 12 December 2017
.../Omi also phosphorylated cofilin and inhibited cofilin-mediated F-actin polymerization. F-actin collapse perturbed lamellipodia formation and therefore impaired cellular migration and invasion. Conclusion: Collectively, our results demonstrate that Hippo-Yap can serve as a tumor promoter in human...
View articletitled, YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways
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Journal Articles

Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo

Open Access
Subject Area:
Further Areas
Jiahang Sun, Xiaoying Gao, Dawei Meng, Yang Xu, Xichun Wang, Xin Gu, Mian Guo, Xiaodong Shao, Hongwen Yan, Chuanlu Jiang, Yongri Zheng
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 43 (2): 636–643.
https://doi.org/10.1159/000480647
Published Online: 22 September 2017
.... Low Mg 2+ -exposed primary neurons were used as an in vitro model of SE. The expression of miR-134 was determined using real-time PCR. Protein expressions of limk1 and cofilin were determined by Western blotting. Luciferase reporter assay was used to examine the binding between miR-134 and limk1 3...
View articletitled, Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo
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