... to in the content or advertisements. Cirrhosis Hepatocellular carcinoma MicroRNA Bioinformatic analysis Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer mortality worldwide [ 1 ]. HCC exists as a high-incidence disease and is usually delayed...

...Sihyung Wang; Youngmi Jung; Jeongeun Hyun; Matthew Friedersdorf; Seh-Hoon Oh; Jieun Kim; Richard T. Premont; Jack D. Keene; Anna Mae Diehl Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis...

...Li Chen; Xiang Cui; Peng Li; Cong Feng; Lili Wang; Hao Wang; Xuan Zhou; Bo Yang; Faqin Lv; Tanshi Li Background/Aims: Keratinocyte growth factor (KGF) plays a critical role in prevention of cirrhosis and enhancement of liver regeneration. However, the molecular regulation of KGF in liver is unknown...

...Dong Ji; Bing Li; Qing Shao; Fan Li; Zhongbin Li; Guofeng Chen Background/Aims: New strategies for the prevention and treatment of cirrhosis are urgently needed for improving therapeutic outcome. A role of microRNAs (miRNAs) in the pathogenesis of cirrhosis has been recently acknowledged, whereas...

...Bing Li; Qing Shao; Dong Ji; Fan Li; Guofeng Chen Background/Aims: Transplantation of mesenchymal stem cells (MSCs) has therapeutic effects on various diseases, while its effect on developing cirrhosis as well as the underlying mechanism remained largely unknown. Methods: Twenty C57BL/6 mice were...