...Niki Prakoura; Panagiotis Kavvadas; Christos E. Chadjichristos Chronic kidney disease is an incurable to date pathology with a continuously growing incidence that contributes to the increase of the number of deaths worldwide. With currently no efficient prognostic or therapeutic options being...

... marker, was shown to increase in chronic kidney disease (CKD), but its role in DN remains unknown. We aim to assess whether CD146 could be used to evaluate disease severity and predict renal outcomes in DN at early stages. Methods: 159 non-dialysis type 2-DN patients from 2008 to 2015 were enrolled...

... acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong...

..., instructions or products referred to in the content or advertisements. [email protected] 7 08 2017 16 01 2018 22 3 2018 Y-box-binding protein 1 Acute kidney injury Chronic kidney disease Translation All authors declare that there are no conflicts of interest...

...Mohammed Al Za’abi; Suhail Al Salam; Yousuf Al Suleimani; Priyadarsini Manoj; Abderrahim Nemmar; Badreldin H. Ali Background/Aims: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non – diabetic rats with adenine...

...Jun Zhou; Jiying Zhong; Sen Lin; Zhenxing Huang; Hongtao Chen; Simin Tang; Chengxiang Yang; Youling Fan Background: Renal fibrosis is a common pathophysiological feature of chronic kidney disease. Acute kidney injury (AKI) is defined as an independent causal factor of chronic kidney disease...

... and Good Laboratory Practice. Mice were monitored daily for body weight and were housed at constant temperature with a 12 h-light/12 h-dark cycle. They were given water and standard chow ad libitum . Chronic kidney disease Alternatively activated macrophages Macrophage plasticity...

... and urinary KIM-1 expression levels were significantly higher in AKI and chronic kidney disease (CKD) patients than in healthy volunteers, and urinary KIM-1 expression was significantly higher in CKD patients than in AKI patients. According to the results of our research involving three different mouse models...

...Shuang Chu; Li Wang; Xiao-dong Mao; Wen Peng Background/Aims: Endothelial dysfunction is a major factor in the progression of chronic kidney disease, which correlates with oxidative stress and NO deficiency. Huangqi decoction (HQD) is a potential anti-oxidant ingredient in renoprotection. However...

...Badreldin H. Ali; Mohammed Al Za''abi; Sirin A. Adham; Javed Yasin; Abderrahim Nemmar; Nicole Schupp Background/Aims: To study the therapeutic effect of chrysin, a flavonoid with strong antioxidant and anti-inflammatory activities, on adenine-induced chronic kidney diseases (CKD) in rats. Methods...

...Wei Ding; Bin Wang; Minmin Zhang; Yong Gu Background/Aims: Uremic cardiomyopathy (UCM) is a complication in chronic kidney disease. We investigated if endoplasmic reticulum stress (ERS) is involved in UCM, and determined the efficacy of tauroursodeoxycholic acid (TUDCA) in UCM prevention. Methods...

... or advertisements. Chronic kidney disease Endothelial nitric oxide synthase Endothelin Mice Nitric oxide Endothelin-1 (ET-1) and nitric oxide (NO) closely interact in a manner of a local network, i.e. ET-1 stimulates NO production, NO in turn inhibits ET-1 expression proportionally in different...

...Wei Ding; Bin Wang; Minmin Zhang; Yong Gu Background: Oxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD) and antioxidants may ameliorate disease progression. We investigate the beneficial effect of Tempol, a superoxide dismutase-mimetic drug, on progression...

...Cong Li; Xiao Yan Ding; Dong Mei Xiang; Jie Xu; Xiang Lan Huang; Fan Fan Hou; Qiu Gen Zhou Background: Macrophage polarization plays a pivotal role in the process of inflammation which is common in chronic kidney disease (CKD). Macrophages polarization under the condition of CKD remains poorly...

... atherosclerosis process characteristic of chronic kidney disease (CKD). Phosphate is an important regulator of VC. Methods: The expression of different smooth muscle cell or osteogenesis markers in response to high concentrations of phosphate or exogenous bone morphogenetic protein 2 (BMP-2) was examined by qRT...

...Guerman Molostvov; Simon Fletcher; Rosemary Bland; Daniel Zehnder Calcium-sensing receptor (CaSR) plays key role in vascular calcification in patients with chronic kidney disease (CKD). We investigated the role of CaSR in regulating smooth muscle cell (SMC) proliferation and apoptosis. Incubation...