...Yi Wang; Lingyan Xu; Xianghu Meng; Zhiqiang Qin; Yamin Wang; Chen Chen; Yichun Wang; Xiang Zhou; Qijie Zhang; Jiadong Xia; Ninghong Song Background/Aims: Urothelial cancer (UC) as a chemotherapy-sensitive tumor, has achieved remarkable progresses in therapeutic paradigm, particularly...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mucoepidermoid carcinoma Protein phosphatase 2A LB100 Chemotherapy...

..., and radiation history showed no correlation with survival rate. However, by univariate analysis, we found that significant adverse predictors of survival were splenic rupture before surgery and large tumor size (> 5 cm), while adjuvant chemotherapy was a favorable predictor. Furthermore, multivariate...

...Juan Huang; Chunxue Gui; Lei Zhang; Feifei Che; Chunsen Wang Background/Aims: Acute myeloid leukemia (AML) is a relapsed and refractory hematological malignancy with a lower morbidity but higher mortality. In addition to hematopoietic stem cell transplantation, chemotherapy is used as the front...

...Haiyan Liu; Yuanmei Zhai; Wenli Zhao; Yun Wan; Wei Lu; Shaoxin Yang; Yehua Yu; Yanyu Wei; Zhiqiang Li; Jun Shi Background/Aims: Chemotherapy is still the main strategy used to prevent the relapse of acute myeloid leukaemia (AML). As the most abundant stromal component in bone marrow (BM), marrow...

... miR-1248, and was augmented by depleting miR-1248. Conclusion: Increased miR-1248 expression in OS may inhibit AGTR1-mediated cancer cell death in chemotherapy. The outcome of chemotherapy may be improved by the suppression of miR-1248 in OS cells. Xiaozhaoyue215@gmail.com 10 07 2017...

... and lymph node metastases. XRCC2 expression might be an independent prognostic indicator for CRC patients. Patients with negative XRCC2 expression exhibit greater sensitivity to treatment with 5-FU-based chemotherapy than those with positive XRCC2 expression. Moreover, our observations revealed...

... survival (OS) and adverse events of chemotherapy were also recorded. Results: The median PFS of patients was 6 months (95% CI, 5.27-6.73) with effective rate of 46.2%. The percentage of CD19 + CD24 h CD27 + cells in lymphocytes ranged from 0.007% to 1.94%, with a median value of 0.45%. The median...

... nucleotide polymorphisms (SNPs) would influence chemotherapy effectiveness and GC prognosis among a Chinese population. Methods: Altogether 430 late-stage GC patients and 960 healthy controls matched with age and sex were incorporated. Three PTPN11 SNPs (i.e. rs7958372, rs12229892 and rs2301756) were...

...Zhiming Wang; Li Liang; Yiyi Yu; Yan Wang; Rongyuan Zhuang; Yong Chen; Yuehong Cui; Yuhong Zhou; Tianshu Liu Background: The effect of primary tumour resection (PTR) among metastatic colorectal cancer (mCRC) patients remains controversial. Combination chemotherapy with bevacizumab could improve...

... R-CHOP chemotherapy. Methods: Flow cytometry (FCM) was applied to measure M-MDSCs (CD14 + HLA-DR low/− M-MDSCs). Results: Analysis of 144 patients with DLBCL under R-CHOP treatment showed that the 5-year overall survival rate was 61.09% (95% CI: 43.72%-72.56%) and the average survival time...

... Bcl-2-mediated cell survival against apoptosis induced by Fluorouracil, while depletion of miR-429 augmented it. Conclusion: Our data suggest that miR-429 suppression in GC promotes Bcl-2-mediated cancer cell survival against chemotherapy-induced cell death. Re-expression of miR-429 levels in GC cells...

... to in the content or advertisements. Human hepatocellular carcinoma cells (HCC) Gefitinib Chemotherapy Apoptosis resistance Des-gamma-carboxy prothrombin (DCP) Antagonistic effect Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide and is the second most frequent...

...Rong Zhang; Wei Yang; Ying Chun Li; Guo Jun Zhang; Kun Yao; Rong Hu; Bin Wu Aim: To investigate the possible association between the Osteopontin (OPN) gene polymorphisms and the susceptibility and chemotherapy response of acute myeloid leukemia patients. Methods: A total of 381 patients with de...

... with treatment response and prognosis of NSCLC patients receiving chemotherapy. Methods: A total of 464 patients with inoperable advanced stage of NSCLC were enrolled. All patients received platinum-based chemotherapy. Meanwhile, the IGF2R expression in tumor samples was detected by Immunohistochemical analysis...

...Chunlei Shi; Jialin Qian; Meili Ma; Yanwei Zhang; Baohui Han Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC). Methods: A total of 594 patients with advanced stage of NSCLC (IIIA...

...Biyuan Zhang; Kejun Zhang; Zimin Liu; Fengyun Hao; Mei Wang; Xiangchun Li; Zongsiu Yin; Hui Liang Background/Aims: Several studies have shown secreted clusterin (sCLU) silencing directed against sCLU mRNA in sCLU-rich lung cancer cell lines sensitized cells to chemotherapy. However, the molecular...

...Fenglei Wu; Jian Zhang; Yi Liu; Yigong Zheng; Nan Hu Aim: To investigate whether the hypoxia-inducible factor-1α (HIF-1α) genetic variants and protein expression affect the chemotherapy response and the clinical outcome of patients with advanced non-small cell lung cancer (NSCLC). Methods: A total...

... of mPTP compounds/modulators and metabolic remodeling. Since the main goal of chemotherapy is to provoke apoptosis, mPT induction may represent an attractive approach for the development of new cancer therapeutics to induce mitochondria-mediated cell death and prevent cell differentiation...

... chemotherapy. Expression of the murine temperature-sensitive mutant p53 vall35 in wild-type (32.5°C), but not mutant (38.5 °C), conformation results in complete growth arrest, but not apoptosis, in three human malignant glioma cell lines, LN-18, LN-229 and LN-308. Here we report that forced expression of p53...