... chemoresistance in human malignant gliomas cells and that inhibition of CCND1 may be an effective means of overcoming CCND1 associated chemoresistance in human malignant glioma cells. Glioblastoma Chemoresistance Temozolomide CCND1 MDR1 Malignant gliomas (anaplastic astrocytoma and glioblastoma...

... is significantly overexpressed in a variety of tumors and associated with anti-cancer drug resistance, however, little is known regarding the expression and function of HOXA-AS2 in the chemoresistance of AML. In this study, we aimed to determine the role and molecular mechanism of HOXA-AS2 in adriamycin-based...

... and typically centered on paclitaxel-based chemotherapy. In this study, we aimed to evaluate whether miR-34a attenuates chemoresistance to paclitaxel by regulating target genes associated with drug resistance. Methods: We used data from The Cancer Genome Atlas to compare miR-34a expression levels in prostate...

...Daifeng Lu; Chuandong Yang; Zhitao Zhang; Yu Cong; Mochao Xiao Background/Aims: The purpose of our experiments was to investigate the targeting relationship of linc00515, miR-140-5p and ATG14 and to explore the roles of linc00515, miR-140-5p and ATG14 in autophagy and chemoresistance of melphalan...

...Xiaobing Liu; Xin Liu; Yuqi Wu; Zhenqiang Fang; Qingjian Wu; Chao Wu; Yaxing Hao; Xia Yang; Jiang Zhao; Jia Li; Qingqing Wang; Zhenxing Yang; Jie Xu; Xiaoyan Hu; Mingjia Tan; Longkun Li Background/Aims: Chemoresistance is largely responsible for relapses of bladder cancer during clinical therapy...

... to 5-FU treatments compared with miR-204 overexpression GC cells. Conclusion: This study describes a miRNA-based therapeutic strategy against 5-FU resistance in GC, contributing to the development of anti-chemoresistance therapeutic agents. Total RNA was extracted using TRIzol Reagent (Invitrogen, CA...

... cancer cell survival, proliferation and chemoresistance. However, the precise fate of glucose metabolism and its role in therapy responsiveness in cancers remains largely unexplored. Methods: The glycolytic phenotype of doxorubicin (ADR)-resistant breast cancer cells and their parental cells was assessed...

...Shixiong Jiang; Chenxin Song; Xinyu Gu; Muhong Wang; Dazhuang Miao; Jiachen Lv; Yanlong Liu Background/Aims: Two major barriers to the successful treatment of colorectal cancer (CRC) are the development of stem cell-like characteristics (stemness) and chemoresistance. Ubiquitin-specific peptidase...

... on the proliferation and chemoresistance of CRC cells. The possible mechanisms of HOTAIR were also explored by fluorescence reporter assay and Western blot. Results: The expressions of HOTAIR were upregulated in CRC tissue tissues compared to adjacent control tissues. We also found HOTAIR was downregulated by miR-203a...

..., and finally influenced autophagy, suggesting that MTDH may activate autophagy via the AMPK/ATG5 signalling pathway. Our findings reveal a unique mechanism by which MTDH promotes GC chemoresistance and show that MTDH is a potential target for improved chemotherapeutic sensitivity and GC patient survival...

... diagnosis and chemoresistance. In this study, we investigated the role of Musashi1 (MSI1) in NSCLC malignancy and chemoresistance. Methods: Colony formation, MTT, glucose uptake and lactate production assays were employed to study lung cancer cell malignancy and chemoresistance. RT-PCR and Western blotting...

...) staining were used to explore ARID1A expression level of the mRNA and protein. Results: We found that miR-144-3p overexpression enhanced cell proliferation, clonogenicity, migration, invasion, and chemoresistance in ccRCC cells. Notably, the oncotumor activities of miR-144-3p were mediated by repressing...

.... Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. Methods: In the current study, we...

... in the harsh environment plays an important role in chemoresistance. However, the role of Beclin-1, a key regulator of autophagy in the drug-resistance of SCLC cells is still poorly understood. In the current study, we focused on the effect and regulation of Beclin-1 in chemoresistance of SCLC cells. Methods...

...Ruijie Zhang; Shenghua Sun; Fuyun Ji; Chun Liu; Hua Lin; Lihua Xie; Honghui Yang; Wenxiang Tang; Yan Zhou; Jianping Xu; Pei Li Background/Aims: Chemoresistance has been a major obstacle to the effective treatment of lung cancer. Previously, we found that contactin-1 (CNTN-1) is related to cisplatin...

... lung adenocarcinoma (LAD). However, chemoresistance remains a major impediment to clinical application of this agent. It has been presented that decreased miR-26a expression lead to cisplatin resistance and promoted growth and migration in human lung cancer. Enhancer of zeste homolog 2 (EZH2...

...Cheng-Shi He; Yi-Cheng Liu; Zhi-Peng Xu; Peng-Chen Dai; Xiao-Wei Chen; De-Hai Jin Background: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus , has been reported to exhibit anti...

..., instructions or products referred to in the content or advertisements. MicroRNA-301a PTEN Melanoma Growth Invasion Migration Chemoresistance Malignant melanoma (MM) is a highly aggressive cancer with a high metastatic potential and rapidly increasing incidence around the world [ 1...

... of epithelial markers such as E-cadherin and β-catenin, and gain in the expression of mesenchymal markers such as N-cadherin, Vimentin and Snail, etc. Increasing evidence suggests a direct molecular and phenotypic correlation between acquisition of EMT characteristics and chemoresistance in tumor cells [ 4,5...

... in the chemoresistance of CRC cells to 5-Fluorouracil (5-FU) is unclear. The aim of this study is to investigate whether miR-149 targets FOXM1 to regulate the 5-FU resistance of CRC. Methods: The qRT-PCR assay was performed to detect the expression of miR-149 in 5-FU-resistant CRC cells (HCT-8/5-FU and LoVo/5-FU...