... disruption and improve ischemic outcomes. Methods: Transient focal cerebral ischemia was induced in rats by a 60-minute middle cerebral artery occlusion, and BHD was orally administrated at the onset of reperfusion, 12 hours later, then twice daily. Assessed parameters on Day 3 after ischemia were...

[email protected] Two phenotypes have been used to identify activated microglia/macrophages. The M1 phenotype represents a detrimental state, characterized by the high expression of pro-inflammatory mediators, which propels the pathological process of cerebral ischemia. The M2 phenotype can increase neuronal...

...Pingping Xia; Yundan Pan; Fan Zhang; Na Wang; E Wang; Qulian Guo; Zhi Ye Background/Aims: Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in the progression of cerebral ischemia-reperfusion injury. However, there has been no study on the application...

... following stroke. Methods: The rat model of focal cerebral ischemia was established by middle cerebral artery occlusion (MCAO) surgery; The neurological outcomes were defined by neurological evaluation and infarct volume; The western blotting and immunofluorescence assays were used to detected the protein...

...Lili Han; Zhiling Dong; Ningning Liu; Fei Xie; Ning Wang Background/Aims: Cerebral ischemia often leads to breakdown of blood–brain barrier (BBB) and vasogenic edema. It remains to be established whether MEG3 is responsible for the hypoxic damage in neural cells. This study aimed to investigate...

... of neuronal stimuli such as inflammation and oxidative stress. In this study, we determined the role played by autophagy and Nrf2-ARE signal pathways in the hippocampus regions in modulating cerebral ischemia under different EST conditions. Methods: Western blot analysis and ELISA were used to determine...

... the effect of EE treatment on neuronal apoptosis in the periinfarct cortex after cerebral ischemia/reperfusion (I/R) injury. Methods: The cerebral I/R injury was established by middle cerebral artery occlusion (MCAO). A set of behavioral tests including the modified neurological severity score (mNSS), limb...

... is increased in the cortex after middle cerebral artery occlusion (MCAO); PPARγ up-regulation contributes to PPARγ activation and is effective in reducing ischemic damage to brain. However, the regulatory mechanism of PPARγ after focal cerebral ischemia in rats is still unclear. In this study, we evaluated...

... coupled with altered functions of ion channels play a major role in regulating post-ischemic seizures [ 1,2,3,4 ]. Nefiracetam Cytokines GABA Seizure Cerebral Ischemia Figure 3 demonstrates that the levels of GABA were significantly less in the parietal cortex, hippocampus and amygdala...

...Xuan Li; Xing Huo; Chongyou Zhang; Xinyu Ma; Fei Han; Guonian Wang Background: Cervical sympathetic blockade has been found to reduce cerebral vascular resistance and improve focal cerebral ischemia/reperfusion injury. In this study, we tested the hypothesis that the sympathetic blockade of high...

...Ran Wang; Yan-yan Liu; Xiao-yu Liu; Shu-wei Jia; Jian Zhao; Dan Cui; Ling Wang Background: Resveratrol has shown potent antioxidant activity in ischemia models. The present study was performed to determine whether resveratrol protects against cerebral ischemia-induced neuronal and myocardial injury...

... administered with Tanshinone IIA (4, 20 and 100 mg/kg/d) for one week, and then subjected to cerebral ischemia by middle cerebral artery occlusion (MCAO) for 2 h. In vitro , cultured neurons were pretreated with Tanshinone IIA (2, 10 and 50 uM) for one week, and then exposed to hypoxia for 24 h. Brain iron...

...Lihua Sun; Jing Ai; Ning Wang; Rong Zhang; Jingyuan Li; Tianzhu Zhang; Wanchen Wu; Pengzhou Hang; Yanjie Lu; Baofeng Yang The mechanisms of myocardial dysfunction and calcium handling disturbance underlying cerebral ischemia remain obscure. Here we for the first time report that acute cerebral...

...Ling Wang; Lihua Sun; Yanli Zhang; Huiwei Wu; Chao Li; Zhenwei Pan; Yanjie Lu; Baofeng Yang Despite prolongation of the QTc interval in humans during cerebral ischemia, little is known about the mechanisms that underlie these actions. Cerebral ischemic model was established by middle cerebral...

...Lihua Sun; Juan Du; Gaoxiao Zhang; Yanli Zhang; Guopin Pan; Ling Wang; Baofeng Yang We have examined whether there is a close link between cerebral ischemia and arrhythmogenesis in rats as well as its possible electrophysiological mechanisms. Cerebral ischemic model was made by middle cerebral...