... implied in many physiological processes and diseases, but the role of Nsm2 in pathogen-host interactions and mycobacterial infections has barely been studied. Methods: We investigated the role of the Nsm2/ceramide system in systemic infection of mice and murine macrophages with Mycobacterium bovis...

... potentially stimulating eryptosis include increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), induction of oxidative stress, and increase of ceramide abundance. The present study explored, whether afatinib induces eryptosis and, if so, whether its effect involves Ca 2+ entry, oxidative stress, and/or ceramide...

... arthritis symptoms, establishing Asm as a potential new therapeutic target in RA. ASM and/or ceramide have also been implicated in autoimmunity: ASM has been shown to be important for mast cell function [ 11 ], ceramide is increased in a chronic colitis model [ 12 ] and in a murine model of multiple...

..., ceramide, caspases, calpain, p38 kinase, protein kinase C, Janus-activated kinase 3, casein kinase 1α, cyclin-dependent kinase 4, AMP-activated kinase, p21-activated kinase 2, cGMP-dependent protein kinase, mitogen- and stress-activated kinase MSK1/2, and ill-defined tyrosine kinases. Inhibitors...

... surface. Signaling involved in the orchestration of eryptosis include increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), oxidative stress, ceramide, as well as activation of staurosporine and chelerythrine sensitive protein kinase C, SB203580 sensitive p38 kinase, D4476 sensitive casein kinase 1...

... 2+ activity ([Ca 2+ ] i ), oxidative stress, increase of ceramide abundance, as well as activation of staurosporine sensitive protein kinase C and/or of SB203580 sensitive p38 kinase. The present study explored, whether perifosine induces eryptosis and, if so, whether its effect involves...

... involved in the stimulation of eryptosis includes increase of cytosolic Ca 2+ activity [Ca 2+ ] i , oxidative stress and ceramide. The present study explored, whether adarotene induces eryptosis and, if so, to test for the involvement of Ca 2+ entry, oxidative stress and ceramide. Methods: Flow cytometry...

... with myriocin (Myr), an inhibitor of ceramide de novo synthesis. We utilized [U 13 C] palmitate isotope tracer infusion and mass spectrometry to measure content and synthesis rate of muscle long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) and ceramide (Cer). Results: HFD led to intramuscular accumulation...

..., ceramide and D4476 sensitive casein kinase. The present study explored the putative effect of quinine on eryptosis and elucidated cellular mechanisms involved. Methods: Phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, cell volume from forward scatter, [Ca 2+ ] i from...

... of erythrocytes, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling involved in the stimulation of eryptosis includes increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ) and ceramide. The present study explored, whether...

... could enter suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), oxidative stress and ceramide. The present...

... increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), oxidative stress and ceramide. The present study explored, whether diosgenin induces eryptosis and, if so, to decipher cellular mechanisms involved. Methods: Flow cytometry was employed to estimate phosphatidylserine exposure at the cell surface from...

...Richard S. Hoehn; Aaron P. Seitz; Peter L. Jernigan; Erich Gulbins; Michael J. Edwards Background: Intestinal ischemia/reperfusion injury (I/R) is a significant cause of morbidity and mortality in surgical patients. Ceramide is a mediator of apoptosis and has been implicated as increasing bacterial...

... eryptosis, a suicidal death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Cellular mechanisms stimulating eryptosis include increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), oxidative stress and ceramide. The present study...

... symptoms. However, the disease has also many symptoms outside the central nervous system, in particular cardiovascular symptoms. Recent studies demonstrated that the acid sphingomyelinase/ceramide system plays an important role in the development of major depressive disorder and functions as a target...

... Ca 2+ activity ([Ca 2+ ] i ), oxidative stress, ceramide, and activation of protein kinase C, p38 kinase, casein kinase, and caspases. The present study explored, whether Dolutegravir induces eryptosis and, if so, to gain insight into cellular mechanisms involved. Methods: Utilizing flow cytometry...

...Constantin Adams; Vanya Icheva; Caroline Deppisch; Josefine Lauer; Gloria Herrmann; Ute Graepler-Mainka; Susanne Heyder; Erich Gulbins; Joachim Riethmueller Background/Aims: Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic...

... surface. Cellular mechanisms involved in the triggering of eryptosis include increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), oxidative stress and ceramide formation. The present study explored, whether Piceatannol induces eryptosis and, if so, to shed some light on the cellular mechanisms involved...

..., while ceramide is massively increased in CF mice. Methods: We investigated the effect of C18-sphingosine and C16-ceramide on S. aureus in vitro . Based on our results we performed pulmonary infections with S. aureus and tested the influence of sphingosine inhalation. Results: In vitro incubation of S...

... to in the content or advertisements. Sphingolipids TBC1D4 (AS160) Fatty acid transporters Diacylglycerol Triacylglycerol Ceramide Skeletal muscles play a dominant role as a key metabolic tissue regulating glucose and lipid homeostasis [ 1 ]. It is well established that glucose uptake requires...