.... NSCLC FOXD1 Vimentin Cell migration Cell invasion Lung cancer is the leading cause of cancer deaths worldwide [ 1 ] and has become the second leading cause of death in China, with an increased incidence of 465% over the past 30 years [ 1, 2 ]. Non-small cell lung cancer (NSCLC) accounts...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CCL20 Giant cell tumor of bone Cell viability Cell migration Osteoclastogenesis Giant cell tumor of bone (GCTB) is one of the most...

... (TNF)-α stimulation. Cell proliferation, cell migration and invasion and drug sensitivity were subsequently assessed using Cell Counting Kit-8, wound healing, and Transwell assays. Results: Immunohistochemical analysis demonstrated that both MTHFD2 and vimentin overexpression was positively associated...

... a key role in cell migration of non-small cell lung cancer (NSCLC). In this study, we report that Forkhead box class O1 (FOXO1) is downregulated in human NSCLC and that silencing of FOXO1 is associated with the invasive stage of tumor progression. Methods: The cell proliferation, migration, and invasion...

... and mechanism of lipid metabolism-related acetyl-CoA synthetase 2 (ACSS2) in RCC development, cell migration and invasion. Methods: Quantitative real-time PCR (qRT-PCR) was used to determine the expression of ACSS2 in cancer tissue and adjacent tissue. The inhibition of ACSS2 expression was achieved by RNA...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. HOXA-AS2 Hepatocellular carcinoma Cell proliferation Cell migration Hepatocellular carcinoma (HCC...

...-kappa-B-kinase-β and casein kinase-1α and consequently degraded by the proteasome via the SCF (βTrCP) ubiquitin ligase [ 60 ]. Failure to degrade PDZ-GEF1 in epithelial cells results in sustained activity of Rap1 and inhibition of cell migration induced by HGF, a potent metastatic factor. Furthermore...

...Melpomeni Tseliou; Ahmed Al-Qahtani; Saud Alarifi; Saad H. Alkahtani; Christos Stournaras; George Sourvinos Background/Aims: Rho GTPases are crucial regulators of the actin cytoskeleton, membrane trafficking and cell signaling and their importance in cell migration and invasion is well- established...

... signaling. Results: Here, we report a direct interaction between SOD1 and CXCR4. We showed that SOD1 interacts directly with the first intracellular loop (ICL1) of CXCR4 and that the CXCL12/CXCR4-mediated regulation of AKT activation, apoptosis and cell migration in prostate cancer (PCa) cells...

... in the experimental groups compared to control rats. Moreover, concomitant reductions in the EMT markers along with cell migration regulators were also observed in parous and STET groups. Hormonal receptor such as GHR, PR, ERα and growth factor receptors IGFR, EGFR and erbB2 were down regulated in the treatment...

... phenotype. OPN knockdown inhibited α v ,β 3 integrin expression in MDA-MB-231 cells, with subsequent inhibition of cell migration and invasion. Knockdown also inhibited the PI3K/Akt/mTOR pathway, promoted expression of the autophagy-related gene products LC3 and Beclin 1, and increased apoptosis. OPN...

... the secretory profile of cultured hBMSCs. Results: CM from cultured hBMSCs exerted excellent host-hBMSCs-recruiting capability, which was significantly promoted by exposure to inflammatory microenvironment. Within inflammatory microenvironment, hBMSCs secreted more chemokines related to cell migration. Finally...

...Ting Fu; Hubert Kalbacher; Werner Hoffmann Background/Aims: The trefoil factor family (TFF) peptide TFF1 is typically secreted by gastric surface mucous cells. These cells are also the major players in gastric restitution, i.e., repair of the stomach mucosa by cell migration after injury. Methods...

... to reach a ∼ 70% confluent monolayer. The three-dimensional hydrogel matrix (Epigel B, without added growth factor, Epinova Biotech, Novara, Italy) were lean onto PAE monolayers in 250 µl of complete cell culture medium containing different amounts of vitamin D3 (1-100 nM) and cell migration was monitored...

...-matrix adhesion by the deposition of a specific extracellular matrix. Targeting PIM1 function therefore might be important to promote endothelial barrier integrity. 1 09 2012 24 9 2012 Cell adhesion PIM1 Extracellular matrix Cell migration Endothelial cells © 2012 S. Karger AG...

... and Adherent ELA Cells Else Kay Hoffmann* Section of Cell and Developmental Biology, Department of Biology, University of Copenhagen, Copenhagen *recipient of the Yasu Okada Medal Key Words VRAC TMEM16 TASK-2 RVD Osmotic stress Cell migration Cell proliferation Programmed cell death Apoptosis...

... in suppression of breast cancer cell invasion and migration that is induced by PMA. Celastrol is a potential agent for clinical use in preventing the invasion and metastasis of human malignant breast tumors. 26 07 2011 16 8 2011 Celastrol MMP-9 Cell migration Cell invasion Breast cancer...

...Eva B. Znalesniak; Werner Hoffmann Mucous epithelia represent a major barrier to the outside world and are capable of undergoing rapid repair after injury by cell migration, a process called “restitution”. Here, a sensitive RT-PCR method was applied allowing systematic gene expression analysis...

... and pathophysiological processes including development and tissue repair. Cell migration is regulated through external stimuli such as platelet-derived growth factor-AA (PDGF-AA), a key regulator in directional cell migration during embryonic development and a chemoattractant during postnatal migratory responses...

...Eva B. Znalesniak; Uwe Dürer; Werner Hoffmann Rapid repair by cell migration, a process called “restitution”, is essential for wound healing of mucous epithelia. Here, an established in vitro model for restitution, i.e., migration of the non-transformed intestinal epithelial cell line IEC-18 after...