...Ling-Fang Wang; Cong-Cong Huang; Yun-Fei Xiao; Xiao-Hui Guan; Xiao-Nv Wang; Qing Cao; Yu Liu; Xuan Huang; Li-Bin Deng; Ke-Yu Deng; Hong-Bo Xin Background/Aims: Previous studies showed that CD38 deficiency protected heart from ischemia/reperfusion injury and high fat diet (HFD)-induced obesity...

...+ uptake. We demonstrate that cADPR is generated by CD38, a cADPR-synthesizing enzyme, increasing muscle Ca 2+ signals and contractile force during exercise. CD38 is upregulated by the cAMP response element–binding protein (CREB) transcription factor upon β-AR stimuli and exercise. CD38 knockout (KO) mice...

... switching of mouse coronary arterial myocytes (CAMs) induced by CD38 gene deficiency or lysosomal dysfunction which blocks autophagic flux in the cells. Methods: Protein expression was measured by western blot analysis and immunofluorescent staining. Cell cycle and proliferation rate were analyzed by flow...

...Ming Xu; Xiao-Xue Li; Lei Wang; Mi Wang; Yang Zhang; Pin-Lan Li Background/Aims: Recent studies have indicated that CD38 gene deficiency results in dedifferentiation or transdifferentiation of arterial smooth muscle cells upon atherogenic stimulations. However, the molecular mechanisms mediating...