...Xiaofang Wang; Yuan Liu; Lili Xiao; Ling Li; Xiaoyan Zhao; Lulu Yang; Ning Chen; Lu Gao; Jinying Zhang Background/Aims: Cardiac hypertrophy is a major predisposing factor for heart failure and sudden cardiac death. Hyperoside (Hyp), a flavonoid isolated from Rhododendron ponticum L ., is a primary...

.... However, the role of NLRP1 in cardiac hypertrophy remains unclear. We used in vivo and in vitro models to investigate the effects of NLRP1 on cardiac hypertrophy. Methods: We used NLRP1-deficient mice and cultured neonatal rat cardiomyocytes with gain and loss of NLRP1 function. Cardiac hypertrophy...

..., and mitochondrial functional capacity were measured in each group. Results: Elevated blood pressure was only observed in HS-fed UCP3 -/- mice. High salt induced cardiac hypertrophy and dysfunction were observed in both C57BL/6 and UCP3 -/- mice. However, the cardiac lesions were more profound in HS-fed UCP3...

...Ming Hu; Zhenhui Zhang; Bin Liu; Shuangwei Zhang; Renjie Chai; Xiaohua Chen; Tianyu Kong; Fangcheng Zhang; Jingzhi Zhang; Shiming Liu; Ningning Liu Background/Aims: Cardiac hypertrophy is a major outcome and compensatory response of the cardiovascular system to hemodynamic and additional stress...

... for the phosphorylation of myosin light chain 2 (MLC2), plays an important role in regulating cardiac muscle contraction and hypertrophy. However, whether Ang II could facilitate cardiac hypertrophy by altering the expression of MLCK remains unclear. This study aimed to investigate this effect and the underlying...

... transverse aortic constriction (TAC) or sham surgery (control group). Beginning one week after surgery, the mice were oral gavage treated with sesamin (100mg·kg -1 ·day -1 ) or vehicle for 3 weeks. Cardiac hypertrophy was assessed by echocardiographic parameters, histological analyses and hypertrophic...

... , a cyclin-dependent kinase inhibitor, has been implicated in cardiac hypertrophy, however, its precise contribution to this process remains largely unclear. Methods: The gene expression profile in left ventricle (LV) of spontaneously hypertensive rats (SHR) and Wistar–Kyoto (WKY) rats was determined using...

...Ning Zhang; Wen-Ying Wei; Zheng Yang; Yan Che; Ya-Ge Jin; Hai-Han Liao; Sha-sha Wang; Wei Deng; Qi-Zhu Tang Background/Aims: An increase in oxidative stress has been implicated in the pathophysiology of pressure-overload induced cardiac hypertrophy. Nobiletin (NOB), extracted from the fruit peel...

.... To identify mechanisms by which Stachydrine inhibits pressure overload-induced cardiac hypertrophy, we determined inhibitory activities against activation of NADPH oxidase, reactive oxygen species(ROS) production and excessive activation of autophagy. Methods: Stachydrine was administered intragastrically...

.... However, the precise mechanism of EPI on cardiomyocyte hypertrophy has not yet been determined. In this study, we examined whether EPI could inhibit cardiac hypertrophy. Methods: We utilised cultured neonatal mouse cardiomyocytes and mice for immunofluorescence, immunochemistry, qRT-PCR, and western blot...

... of heart/body weight index and heart weight /tibia length index, compared with control mice. Atv treatment attenuated cardiac hypertrophy induced by cold exposure; Atv also attenuated the increase of cross-sectional area of cardiomyocytes and cardiac collagen content fraction in mice exposed to cold. ECG...

... or advertisements. Cardiac hypertrophy Resveratrol Endoplasmic reticulum stress Apoptosis Cardiovascular diseases remain the leading causes of death and disability in the world. During the pathological development of cardiovascular diseases, cardiac hypertrophy plays a critical role. Although...

... Tissue inhibitors of matrix metalloproteinases Amlodipine Atorvastatin Cardiac hypertrophy Spontaneous hypertension Myocardial tissue is mainly composed of cardiomyocytes and extracellular matrix (ECM). ECM includes collagen, proteoglycans, glycoproteins, glycosaminoglycans and elastin fibers...

...Yan Lin; Xiaojie Zhang; Wei Xiao; Bo Li; Jun Wang; Li Jin; Jie Lian; Li Zhou; Jicheng Liu Background/Aims: Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy. This involves an increase...

...Perla Pérez-Treviño; Jorge Pérez-Treviño; Cuauhtémoc Borja-Villa; Noemí García; Julio Altamirano Background/Aims: Pressure-overload (PO) causes cardiac hypertrophy (CH), and eventually leads to heart failure (HF). HF ventricular myocytes present transverse-tubules (TT) loss or disarrangement...

...Jakob Voelkl; Tatsiana Castor; Katharina Musculus; Robert Viereck; Sobuj Mia; Martina Feger; Ioana Alesutan; Florian Lang Background/Aims: The serum- and glucocorticoid-inducible kinase SGK1 participates in the orchestration of cardiac hypertrophy and remodeling. Signaling linking SGK1 activity...

... using adult male mice expressing TRβ Δ337T , which contains the Δ337T mutation of the human THRB gene and impairs ligand binding. Cardiac function and RNA expression were studied after hypo-or hyperthyroidism inductions. T3-induced cardiac hypertrophy was not observed in TRβ Δ337T mice, showing...

... dysfunction and cardiac hypertrophy and this phenomenon could, in part, be mediated by the Ca 2+ /CaM-dependent CaN pathway and p38 mitogen-activated protein kinase (MAPK) signal pathway in rats. 6 07 2015 17 8 2015 © 2015 S. Karger AG, Basel 2015 Open Access License / Drug Dosage...

... of cardiac hypertrophy. We aimed to identify sensing sites of AT 1 R for activation by mechanical stretch. Methods: We constructed several site-directed mutations of AT 1 R (AT 1 R K199Q , AT 1 R L212F , AT 1 R Q257A and AT 1 R C289A ), transfected them respectively into COS7 cells or angiotensinogen...

...Lei Liu; Chao Wang; Dianjun Sun; Shuangquan Jiang; Hong Li; Weihua Zhang; Yajun Zhao; Yuhui Xi; Sa Shi; Fanghao Lu; Ye Tian; Changqing Xu; Lina Wang Background/Aims : Intracellular calcium concentration ([Ca 2+ ] i ) homeostasis, an initial factor of cardiac hypertrophy, is regulated by the calcium...