...JingChao Zhang; Yan Lang; LongHui Guo; Yu Pei; Shuang Hao; ZhenXing Liang; Gang Su; LiLiang Shu; Hai Liu; Chen Huang; Jing Xu Background/Aims: Cardiac fibrosis is a major cause of diverse cardiovascular diseases. MicroRNAs have recently been proven a novel class of regulators of cardiac fibrosis...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Anoctamin-1 Calcium-activated chloride channels Cardiac fibroblasts Cardiac fibrosis...

...LiJun Qian; Jian Hong; YanMei Zhang; MengLin Zhu; XinChun Wang; YanJuan Zhang; Ming Chu; Jing Yao; Di Xu Background/Aims: Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains...

...Xiaoxiao Liu; Yifeng Xu; Yunfei Deng; Hongli Li Background/Aims: Percutaneous coronary intervention reduces acute myocardial infarction (MI)-induced mortality to a great extent, but effective treatments for MI-induced cardiac fibrosis and heart failure are still lacking. MicroRNAs (miRNAs) play...

... administration on pressure overload–induced cardiac fibrosis in mice and reveal the underlying mechanisms of aspirin treatment. Methods: C57BL/6 mice were subjected to transverse aortic constriction (TAC), and treated with 10 mg·kg -1 ·day -1 of aspirin for 4 weeks. Masson staining and a collagen content assay...

...Wen-Ying Wei; Ning Zhang; Ling-Li Li; Zhen-Guo Ma; Man Xu; Yu-Pei Yuan; Wei Deng; Qi-Zhu Tang Background/Aims: Cardiac fibrosis, characterized by an unbalanced production and degradation of extracellular matrix components, is a common pathophysiology of multiple cardiovascular diseases. Recent...

...Yuan Liu; Lu Gao; Sen Guo; Yuzhou Liu; Xiaoyan Zhao; Ran Li; Xiaofei Yan; Yunpeng Li; Shuai Wang; Xiaoyu Niu; Liantao Yao; Yanzhou Zhang; Ling Li; Haibo Yang Background/Aims: Endothelial-to-mesenchymal transition (EndMT) is a mechanism that promotes cardiac fibrosis induced by Angiotensin II (AngII...

... to in the content or advertisements. H3 relaxin Diabetic cardiomyopathy NLRP3 inflammasome Apoptosis Cardiac fibrosis Diabetic cardiomyopathy (DCM) is a specific cardiomyopathy that develops in diabetic patients independently of coronary heart disease and hypertension [ 1, 2 ]. Despite...

...Jinxia Yuan; Hongtao Chen; Dawei Ge; Yu Xu; Haihua Xu; Yang Yang; Ming Gu; Yuhe Zhou; Jingdong Zhu; Ting Ge; Qun Chen; Yue Gao; Yanqing Wang; Xiaowei Li; Yanfang Zhao Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as an important factor in the deterioration...

..., instructions or products referred to in the content or advertisements. Relaxin Spironolactone Cardiac fibrosis Transforming growth factor β Endothelial-mesenchymal transition Cellular Physiology Cell Physiol Biochem 2017;41:1167-1178 and Biochemistry DOOII::1100.1.1115599/0/000464461421525...

...Yuan Hong; Huaming Cao; Qiang Wang; Jianlin Ye; Lijun Sui; Jinhua Feng; Xiaojun Cai; Huizhu Song; Xiuhong Zhang; Xichuang Chen Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure, but the mechanisms undelying...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. TGF-β Cardiac fibrosis PPARγ Smad3 mSin3A Accumulating evidence has shown...

... causes for heart disease. Our study was designed to investigate the role of microRNA-328 (miR-328) in regulating cardiac fibrosis. Methods: We induced cardiac fibrosis following MI by occlusion of the left coronary artery in C57BL/6 mice. Real-time PCR was employed to evaluate the level of miR-328...

...Peng Deng; Ling Chen; Zheng Liu; Ping Ye; Sihua Wang; Jie Wu; Yufeng Yao; Yuan Sun; Xiaofan Huang; Linyun Ren; Anchen Zhang; Ke Wang; Chuangyan Wu; Zhang Yue; Xuezeng Xu; Manhua Chen Background/Aims: Cardiac fibrosis is the primary cause of deteriorated cardiac function in various cardiovascular...

...Guang-Pu Fan; Wei Wang; Hui Zhao; Lin Cai; Pei-De Zhang; Zi-He Yang; Jing Zhang; Xu Wang Background: To investigate the role of focal adhesion kinase (FAK)-mediated signaling in hypoxia-induced cardiac fibroblasts (CFs) differentiation and cardiac fibrosis post-myocardial infarction (MI) on a mice...

...Dan Zheng; Shiyun Dong; Ting Li; Fan Yang; Xiangjing Yu; Jichao Wu; Xin Zhong; Yajun Zhao; Lina Wang; Changqing Xu; Fanghao Lu; Weihua Zhang Background: Oxidative stress inducing hyperglycemia and high glucose play an important role in the development of cardiac fibrosis associated with diabetic...

... aberrant cardiac remodeling. Transforming growth factor beta (TGF-β) signaling pathway plays a pivotal role in mediating cardiac fibroblast (CF) function and cardiac fibrosis. Recent data suggested that microRNA-101a (miR-101a) exerted anti-fibrotic effects in post-infarct cardiac remodeling and improved...

... metalloproteinase-3 and -9 (MMP-3 and -9). Activation of CaR promoted cardiac fibroblast proliferation and migration and ECM secretion. More importantly, calhex231, suppressed cardiac fibroblast proliferation and migration and MMP-3 and -9 expression. To further investigate the effect of CaR on cardiac fibrosis...

..., instructions or products referred to in the content or advertisements. High glucose Hyperglycemia Diabetes STAT1 STAT3 ERK1/2 Cardiac fibroblast Collagens I and III Cardiac fibrosis S31-201 Fludarabine Long-term diabetes can result in the development of diabetic cardiomyopathy...