... type of non-protein encoding transcript, and are > 200 bp in length [ 14, 15 ]. Recently, many lncRNAs have been reported to play important roles in tumorigenesis, cancer progression and drug resistance [ 16-18 ]. Furthermore, evidence of circulating lncRNAs as biomarkers is rapidly increasing...

... of cancer. Hepcidin secreted by liver plays an essential role in orchestrating iron metabolism. In the present study, we aimed to investigate the ability of angelica sinensis polysaccharide (ASP) to decrease iron burden in tumor-bearing mice and the mechanism of ASP regulation hepcidin expression. Methods...

...Wei Yan; Tao Yang; Jianhong Yang; Taijin Wang; Yamei Yu; Yuxi Wang; Qiang Chen; Peng Bai; Dan Li; Haoyu Ye; Qiang Qiu; Yongzhao Zhou; Yiguo Hu; Shengyong Yang; Yuquan Wei; Weimin Li; Lijuan Chen Background/Aims: Many tubulin inhibitors are in clinical use as anti-cancer drugs. In our previous study...

... to subfertility and increased risk for cancer development being pathologies associated with hemodialysis. For miRNA profiling serum samples were collected from three men: 1) age 43, time on dialysis 74 months, unknown kidney disease, 2) age 44, time on dialysis 25 months due to polycystic kidney disease, and 3...

...Rong-quan He; Mei-jiao Qin; Peng Lin; Yi-Huan Luo; Jie Ma; Hong Yang; Xiao-hua Hu; Gang Chen Background/Aims: Whether the level of long noncoding RNA plasmacytoma variant translocation 1 gene (lncRNA PVT1) expression influences the clinical development and outcome of human cancers has not been...

... several signaling pathways in the cells, e.g. generation of endoplasmic reticulum stress, oxidative status of the cells, etc. Melatonin has been shown to exert antiproliferative and cytotoxic effects on various human cancers. We proposed that this hormone can differently affect tumour cells and healthy...

... of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer...

... mutations to unprecedented levels of precision, especially in cancer-associated genes. dPCR has been utilized in the detection of tumor markers in cell-free DNA (cfDNA) samples from patients with different types of cancer in samples such as plasma, cerebrospinal fluid, urine and sputum, which confers...

..., cell migration, cell adhesion and apoptosis. A number of studies have found that CIB1 is ubiquitously expressed and is related to various human diseases, such as cancer, Alzheimer’s disease (AD), cardiac hypertrophy and male infertility. The mechanism of CIB1 in human diseases is still not clear...

...Xiulian Li; Ying Lan; Yanli He; Yong Liu; Heng Luo; Haibo Yu; Ni Song; Sumei Ren; Tianwei Liu; Cui Hao; Yunliang Guo; Lijuan Zhang Background/Aims: Bleomycin is a clinically used anti-cancer drug that produces DNA breaks once inside of cells. However, bleomycin is a positively charged molecule...

..., lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently...

... as dual regulators of cancer development by acting on multiple signaling pathways, thereby act as novel biomarkers for cancer diagnosis, prognosis, and prediction of response to treatment. As one of them, miR-30a has been found to act as an onco-suppressor of tumorigenesis pathways through inhibition...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. VPS13A Orai1 NFκB SGK1 SOCE Cancer The protein chorein interacts with the phosphoinositide-3-kinase (PI3K...

... and progression of human cancers. Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR), was first discovered in induced pluripotent stem cells (iPSCs), where it was controlled by the key pluripotency factors Oct4, Sox2 and Nanog. Linc-ROR has been shown to be dysregulated in many types...

...Zhimeng Ye; Zhuojun Zheng; Xiaodong Li; Yuandong Zhu; Zhaoping Zhong; Linrui Peng; Yanyan Wu Background: B7-H3 exhibits altered expression in various cancers. However, the correlation between B7-H3 expression and prognosis of cancer patients remains controversial. Therefore, we elicit a meta...

... and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy. 12 05 2016 20 6 2016 © 2016 The Author(s) Published by S. Karger AG, Basel 2016 Open Access License / Drug...

... the K382 acetylation of p53, which lead to the stabilization of p53 in human gastric cancer cell line MGC-803 cells. Meanwhile, we also found compound 3a can inactivate SIRT2 in cells, which suggests the compound as a non-selective SIRT inhibitor. Conclusion : All these findings indicate that compound 3a...

..., or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cancer...

...: By in vitro kinase activity inhibition assays, cell cycle and viability analysis in human cancer model systems, we describe the biologic effects of a recently identified kinase inhibitor, SI113, characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffold, that shows specificity for Sgk1. Results: SI113...

...Yingjie Shao; Yiting Geng; Wendong Gu; Jin Huang; Honglei Pei; Jingting Jiang Background: Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may serve as prognostic biomarkers. We performed a systematic review and meta-analysis to evaluate...