.... After 24h of treatment, supernatants (SN) and cell lysates (Lys) were collected for immunoblot analysis. And the rat p-MΦ polarized M1MΦ SN were cocultured with cardiac fibroblasts for an additional 24h. Myocardial infarction Macrophage Calcium sensing receptor NLRP3 inflammasome Cardiac...

...-lyase (CSE), a major enzyme that produces H 2 S, is regulated remains unknown. Whether calcium-sensing receptor (CaSR) inhibits the proliferation of VSMCs by regulating the endogenous CSE/H 2 S pathway in diabetic rat has not been previously investigated. Methods and Results: The morphological...

... concentrations ([Ca 2+ ] i ) at its onset. The calcium sensing receptor (CaSR) is a G-protein coupled receptor, however, the functional involvement of CaSR in diabetic encephalopathy remains unclear. Methods: In this study, diabetic rats were modeled by STZ (50 mg/kg). At the end of 4, 8 and 12 weeks, the CaSR...

... including activation of the calcium sensing receptor (CaSR) and a yet undefined mechanism. In the present study, we investigated the CaSR-independent molecular mechanism by which SrRan stimulates osteoblast growth. Methods: MC3T3-E1 and primary osteoblastic cells, specific inhibitors of receptor tyrosine...

...Giovanna Valenti; Annalisa Mira; Lisa Mastrofrancesco; Domenica Rita Lasorsa; Marianna Ranieri; Maria Svelto In this work, we studied G protein-coupled Extracellular Calcium Sensing Receptor (CaR) signaling in mouse cortical collecting duct cells (MCD4) expressing endogenous CaR. Intracellular [Ca...

...Ann Stepanchick; Jennifer McKenna; Olivia McGovern; Ying Huang; Gerda E. Breitwieser Calcium sensing receptor (CaSR) mutations implicated in familial hypocalciuric hypercalcemia, pancreatitis and idiopathic epilepsy syndrome map to an extended arginine-rich region in the proximal carboxyl terminus...