... Hyperosmolarity Oxidative stress Ionomycin Calcium Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 The Anaplastic lymphoma kinase (ALK) inhibitor [ 1-3 ] Alectinib is used for the treatment of ALK positive non-small-cell lung cancer (NSCLC) [ 1-20 ]. Alectinib is at least...

..., instructions or products referred to in the content or advertisements. Phosphatidylserine Cell volume Eryptosis Calcium Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 Taurolidine is an effective antibacterial substance [ 1-8 ] utilized to counteract catheter-related...

...-activated protein kinase (AMPK), a key regulator of glucose and fatty acid metabolism, plays a major role in obesity and type 2 diabetes. Accumulating evidence suggests that TRPC6 channels are crucial mediators of calcium transport in podocytes and are involved in regulating glomerular filtration. Here we...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phosphatidylserine Cell volume Eryptosis Calcium Costunolide, a sesquiterpene lactone isolated from Inula helenium (Compositae) [ 1, 2 ], has previously been shown...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Yeast mitochondria Mitochondrial megachannel Permeability transition F-ATP synthase Calcium The permeability transition is a Ca 2+ - dependent increase...

...), and the changes of the intracellular Ca 2+ levels were monitored by use of Calcium Green in the presence or absence of LAT-A. The concomitant changes of the actin cytoskeleton were visualized with fluorescent F-actin probes in confocal microscopy. Results: We have shown that the LAT-A-induced Ca 2+ increases...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phosphatidylserine Eryptosis Energy depletion Oxidative stress Hyperosmotic shock Ionomycin Calcium The smoothened (SMO) inhibitor sonidegib interferes...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Afatinib Eryptosis Phosphatidylserine Calcium Oxidative stress Ceramide Afatinib, a second generation epidermal growth factor receptor ( EGFR ) tyrosine kinase...

... was collected, and we focused on the differences in the concentrations of calcium, uric acid, low density lipoprotein and homocysteine. The dataset GSE11583 from the Gene Expression Omnibus database was analyzed to find the potential mechanism using bioinformatics methods. Results: Among the four metabolites...

... mechanisms remain unclear. This study aimed to delineate the possible mechanisms involving bubble-induced EMPs formation. Methods: Human umbilical vein endothelial cells (HUVECs) were contacted by bubbles and EMPs level in supernatant were quantified by flow cytometry. Cytoplasmic calcium (Ca 2...

... the percentage of annexin V-binding erythrocytes and the intracellular calcium concentration ([Ca 2+ ] i ). IDM (3-12 µM) did not significantly modify the ceramide level or DCFH-DA fluorescence. Energy depletion (removal of glucose for 24 hours) significantly increased annexin V binding and Fluo-3 fluorescence...

... cells. Methods: We compared the effect of 24 h melatonin treatment on calcium transport (by fluorescent probes FLUO-3AM and Rhod-5N), ER stress (determined as changes in the expression of CHOP, XBP1 and fluorescently, using Thioflavin T), ROS formation (by CellROX® Green/Orange Reagent) and apoptosis...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phosphatidylserine Eryptosis; energy depletion Oxidative stress Hyperosmotic shock Ionomycin Calcium Volasertib The Polo-like kinase 1...

...Xianwang Wang; Xiaochun Peng; Xueqing Zhang; Hanyi Xu; Chengbiao Lu; Lian Liu; Jiaxing Song; Yingjie Zhang Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation...

... Calcium Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 The anaplastic lymphoma kinase (ALK) originally detected in anaplastic large cell lymphomas (ALCL) [ 1 ] plays a decisive pathophysiological role in several solid tumors [ 1 ], including ALK expressing non-small cell...

.... Phosphatidylserine Cell membrane scrambling Oxidative stress Calcium Simvastatin, a 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase inhibitor decreasing cholesterol synthesis [ 1 ], is widely used for the treatment of dyslipidemia with hypercholesterolemia [ 2-15 ]. Further putative therapeutic...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. RBC Calcium Cell volume Cell membrane scrambling ROS Ceramide Glutathion...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. NCX1 NCKX1 NCKX2 NCKX5 Calcium p38 kinase SGK1 NF-κB Deutsche Foschungsgemeinschaft (DFG) 10.13039...

... susceptibility to apoptosis. Both, decreased SOCE and enhanced apoptosis of ChAc fibroblasts can be reversed by lithium treatment. [email protected] 9 05 2017 20 05 2017 11 8 2017 Calcium SOCE Lithium Apoptosis Neurodegeneration Orai1 Cell membrane scrambling...

... induces phosphatidylserine exposure, cell shrinkage, and calcium influx, whether it impairs S-nitrosylation and whether these effects are inhibited by NO. Methods: Phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, cell volume from forward scatter, [Ca 2+ ] i from Fluo3...