... and relocation of CREB-CBP complex in vivo and in vitro . Conclusion: C20 plays importantly reno-protective roles most likely through the relocation of CREB-CBP complex. [email protected] 30 01 2018 2 10 2018 11 10 2018 © 2018 The Author(s). Published by S. Karger AG, Basel...

...). Mechanistically, resistin inhibited the activation of CREB, resulting in suppression of PGC-1α. Importantly, overexpressing PGC-1α can rescue the inhibitory effects of resistin on fatty acid β oxidation. Conclusions: Activating the transcriptional activity of CREB using small molecular chemicals is a potential...

.... Western blot and immunofluorescence were employed to detect the expression of β-site APP cleaving enzyme 1 (BACE1) and c-AMP response element-binding protein (CREB). Results: Learning and memory were significantly impaired in 2VO rats, and these changes were accompanied by neuronal loss and glial...

... explored the detail role of PKA/CREB signaling in BMP9-induced osteogenic differentiation. Methods: Activation status of PKA/CREB signaling is assessed by nonradioactive assay and Western blot. Using PKA inhibitors and a dominant negative protein of CREB (A-CREB), we investigated the effect of PKA/CREB...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CREB ERK Macrophage LPS MMP-9...

... identified and most cell types express different proportions of these isoforms. The purpose of this study was to investigate how IP 3 R signalling is involved in the activation of the Ca 2+ -sensitive transcription factors NFAT and CREB. Methods: Each IP 3 R isoform expressed in HEK 293A cells was knocked...

... a higher rate of glucose consumption. The transcription factor CREB (cAMP response element binding protein) was activated with decreasing oxygen tensions in both cell types. This effect was again more marked in A549 cells, demonstrating epithelial cells to be more oxygen sensitive. Activating Transcription...