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Keywords: CFTR
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Cellular Physiology and Biochemistry (2018) 51 (3): 1489–1499.
Published Online: 28 November 2018
...Inna Sabirzhanova; Clément Boinot; William B. Guggino; Liudmila Cebotaru Background/Aims: Cystic fibrosis (CF) is a lethal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR). ΔF508, the most common mutation, is a misfolded protein that is retained...
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Cellular Physiology and Biochemistry (2018) 45 (4): 1551–1565.
Published Online: 21 February 2018
... that altered acid base transport machinery in the kidney collecting duct underlies the mechanism of impaired bicarbonate elimination in the CF kidney. Methods: Balance studies in metabolic cages were performed in WT and CFTR knockout (CF) mice with the intestinal rescue in response to bicarbonate loading...
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Cellular Physiology and Biochemistry (2017) 44 (3): 1146–1160.
Published Online: 27 November 2017
...-promoting activation and cystic fibrosis transmembrane conductance regulator (CFTR) expression of the bioactive herbal monomer naringenin. Methods: Vectorial Cl - transport was determined by measuring short-circuit current ( I SC ) in rat airway epithelium. cAMP content was measured by ELISA in primary...
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Cellular Physiology and Biochemistry (2016) 39 (6): 2262–2274.
Published Online: 07 November 2016
...Jing Chen; Yu Chen; Yajie Chen; Zicheng Yang; Bo You; Ye Chun Ruan; Yizhi Peng Background: CFTR is implicated in cutaneous wound healing although the underlying mechanisms are not fully understood. In other cell types, CFTR is reported to regulate MAPK/ NF-κB signaling. We undertook the present...
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Cellular Physiology and Biochemistry (2016) 39 (2): 565–572.
Published Online: 11 July 2016
..., methods, instructions or products referred to in the content or advertisements. Cystic Fibrosis Amitriptyline Ceramide CFTR Cystic fibrosis (CF) is the most common autosomal recessive disorder in western countries. The disease is caused by mutations in the cystic fibrosis transmembranous...
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Cellular Physiology and Biochemistry (2013) 31 (1): 153–165.
Published Online: 01 February 2013
...-GAP on CFTR trafficking were studied in CFBE41o- Kir 2.2 and MDCK cell lines stably expressing CFTR using a transient transfection system. Results: Transient transfection of ExoS-GAP increased the total and surface protein levels of mature wild type CFTR in epithelial cells stably expressing wild type...
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Cellular Physiology and Biochemistry (2012) 30 (5): 1120–1133.
Published Online: 05 October 2012
...Filipa Mendes; Carlos M. Farinha; Verónica Felício; Paulo C. Alves; Isabel Vieira; Margarida D. Amaral Background: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the dysfunctional Cl - channel in Cystic Fibrosis, undergoes complex biosynthesis at the endoplasmic reticulum involving...
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Cellular Physiology and Biochemistry (2012) 30 (4): 1023–1038.
Published Online: 20 September 2012
...Hiromi Uramoto; Toshiaki Okada; Yasunobu Okada Background: The cardiac isoform of the cystic fibrosis transmembrane conductance regulator (CFTR) was shown to be activated by β-adrenergic or purinergic stimulation and involved in cell volume regulation after osmotic swelling. Also, cardiac CFTR...
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Cellular Physiology and Biochemistry (2012) 30 (3): 587–595.
Published Online: 25 July 2012
...Andrea van Barneveld; Isabell Zander; Rebecca Hyde; Florian Länger; André Simon; Marcus Krüger; Manfred Ballmann; Nico Derichs; Burkhard Tümmler Background/Aims: Knowledge about the abundance and distribution of CFTR protein glycoforms in native lung tissue is scarce. For upcoming studies...
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Cellular Physiology and Biochemistry (2012) 29 (5-6): 775–790.
Published Online: 11 May 2012
... CFTR gene (e.g. ΔF508-CFTR), it was assumed that sildenafil could be a promising substance to correct impaired protein expression. This study focuses on the molecular mechanisms of sildenafil on CFTR recovery. We used ΔF508-CFTR/wt-CFTR expressing Xenopus laevis oocytes and human bronchial epithelial...
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Cellular Physiology and Biochemistry (2011) 28 (6): 1255–1264.
Published Online: 16 December 2011
...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CFTR Cystic fibrosis transmembrane regulator LPA receptors mpkCCD cl4 cells National Institutes of Health (NIH...
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Cellular Physiology and Biochemistry (2011) 28 (4): 715–724.
Published Online: 14 December 2011
...Jiraporn Ousingsawat; Patthara Kongsuphol; Rainer Schreiber; Karl Kunzelmann Previous reports point out to a functional relationship of the cystic fibrosis transmembrane conductance regulator (CFTR) and Ca 2+ activated Cl - channels (CaCC). Recent findings showing that TMEM16A forms the essential...
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Cellular Physiology and Biochemistry (2011) 28 (2): 239–250.
Published Online: 16 August 2011
... comprising the genistein-stimulated secretion. The forskolin-stimulated (10 µM) I sc was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 µM) and CFTR inh -172 (100 µM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl...
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Cellular Physiology and Biochemistry (2010) 26 (4-5): 563–576.
Published Online: 29 October 2010
... the modulation of plasma membrane H + -ATPase by chloride channels, in particular, CFTR and ClC-5 in kidney proximal tubule. Methods and Results: Using in vivo stationary microperfusion, it was observed that ATPase-mediated HCO 3 - reabsorption was significantly reduced in the presence of the Cl - channels...
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Cellular Physiology and Biochemistry (2009) 24 (5-6): 335–346.
Published Online: 04 November 2009
...Anabela S. Ramalho; Marzena A. Lewandowska; Carlos M. Farinha; Filipa Mendes; Juan Gonçalves; Celeste Barreto; Ann Harris; Margarida D. Amaral Background/Aims: Mutations in the CFTR gene cause Cystic Fibrosis (CF) the most common life-threatening autosomal recessive disease affecting Caucasians. We...