... in the progression of breast cancer and its possible mechanisms. Materials: We firstly screened out PGK1 by performing an RT-PCR array of glycolysis-related genes in three paired breast cancer samples, and further investigated PGK1 using TCGA and our own database. The effect and mechanism of PGK1 on cell invasion...

.... Nevertheless, the exploration between circRNAs and pathogenesis of breast cancer (BC) is limited. Previously, circ_0005230 was identified upregulated in BC tissues screened by circRNA microarray. In the present study, we aimed to investigate the expression pattern, functional role, and mechanism...

...Rong-quan He; Dan-dan Xiong; Jie Ma; Xiao-hua Hu; Gang Chen; Wei-liang Sun Background/Aims: The activating molecule in Beclin1-regulated autophagy (Ambra1) has been observed to be over-expressed in several cancers, but the clinical contribution of Ambra1 in breast cancer (BC) remains unknown. Hence...

... and its requirement for tumor survival has been demonstrated in glioma, lung, and prostate cancers. However, whether PFKFB4 plays a role in the tumor metastasis remains uncertain. This study explores the role of PFKFB4 in tumor metastasis and its underlying mechanisms in breast cancer cells. Methods...

... to a poor prognosis and chemoresistance in breast cancer patients. Although Grb2-associated binding protein 2 (Gab2) is important in the development and progression of human cancer, its effects and mechanisms in HER2-overexpressing breast cancer are unclear. Methods: Clone formation and MTT assays were used...

...Kholoud Arafat; Elham Al Kubaisy; Shahrazad Sulaiman; Sherif M. Karam; Zeina Al Natour; Ahmed H. Hassan; Samir Attoub Background/Aims: Breast cancer is the most common cancer in women worldwide, and within this cancer type, triple-negative breast cancers have the worst prognosis. The identification...

...Jun Li; Mingjie Lu; Jiao Jin; Xiyi Lu; Tongpeng Xu; Shidai Jin Background/Aims: Most of estrogen receptor positive breast cancer patients respond well initially to endocrine therapies, but often develop resistance during treatment with selective estrogen receptor modulators (SERMs...

... growth stimulation in several human malignant tumors, including breast cancer. However, the mechanisms underlying the carcinogenic actions of FGF18 remain unclear. Methods: The transcription level of FGF18 under the hypoxic condition was detected with quantitative PCR (qPCR). A wound-healing assay...

...Peng Xing; Huiting Dong; Qun Liu; Tingting Zhao; Fan Yao; Yingying Xu; Bo Chen; Xinyu Zheng; Yunfei Wu; Feng Jin; Jiguang Li Background/Aims: This study aimed to explore the prognostic value of aldehyde dehydrogenase 1 (ALDH1) expression and vasculogenic mimicry (VM) in patients with breast cancer...

... of cancer biology in humans. The present study aims to investigate the role of the lncRNA KCNQ1OT1 in breast cancer (BRCA) as well as the underlying molecular mechanisms and functions of KCNQ1OT1 involved in the progression of BRCA. Methods: The Cancer Genome Atlas (TCGA) and StarBase v2.0 were used...

...Chunxiao Sun; Fan Yang; Yanhong Zhang; Jiahui Chu; Jian Wang; Yifan Wang; Yanqiu Zhang; Jun Li; Yongfei Li; Ruihua Fan; Wei Li; Xiang Huang; Hao Wu; Ziyi Fu; Zefei Jiang; Yongmei Yin Background/Aims: Resistance to trastuzumab remains a common challenge to HER-2 positive breast cancer. Up until now...

... the diagnostic values of estrogen receptor (ER), progesterone receptor (PR), folate receptor (FR) and human epidermal growth factor receptor 2 (HER-2)-targeted molecular probes in the MRI diagnosis of breast cancer. Methods: Initially, a total of 508 female breast cancer patients were selected for breast cancer...

...Shenglong Zhu; Ninghan Feng; Guangxiao Lin; Yuelin Tong; Xuan Jiang; Qin Yang; Shunhe Wang; Wei Chen; Zhao He; Yong Q Chen Background/Aims: Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders...

... in malignant transformation, but the prognostic role, if any, of miRNAs in breast cancer remains undetermined. Therefore, we assessed the prognostic significance of microRNA-9 (miR-9) and miR-221 in breast cancer toward the goal of understanding the contribution(s) of these miRNAs to cancer cell stemness...

... of these transcripts responsible for their dysregulation in breast cancer (BC) are not thoroughly understood. Methods: We examined the expression of microRNA miR-1471 in BC specimens. Online analysis tools predicted that lncRNA LOC101930370 might act as an endogenous ‘sponge’ by competing for miR-1471 binding targets...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Gas5 MiR-23a ATG3 CeRNA Breast cancer Autophagy Cellular Physiology Cell Physiol Biochem 2018;48:194-207 and Biochemistry DOOII::1100.1.1115599/0...

... in breast cancer. Methods: Expressions of linc00518, miR-199a and MRP1 were evaluated by RT-qPCR or western blot. IC 50 values of adriamycin (ADR), vincristine (VCR) and paclitaxel (PTX) were determined by XTT assays and cell apoptosis was assessed by flow cytometry. Luciferase reporter and RIP assays were...

... breast cancer risk. The aim of this study was to investigate effects of single-nucleotide polymorphisms (SNPs) in FGFR1 on breast cancer susceptibility and FGFR1 protein expression. Methods: SNPs rs17182023, rs17175624 and rs10958704 in FGFR1 were genotyped in 747 breast cancer cases and 716 healthy...

...Jian Hao; Ziqi Jin; Hongxu Zhu; Xiaohui Liu; Yu Mao; Xue Yang; Li Gao; Dan Liu; Dan Chen; Xiongzhi Wu Background/Aims: The Xi-Huang (XH) formula has been used for breast cancer treatment in traditional Chinese medicine (TCM) since 1740. In this study, we show that, XH extract could suppress...

... is functionally linked to Jab1 in breast cancer. Methods: In situ hybridization and immunohistochemical analyses were used to determine the level of let-7d and Jab1 in breast cancer clinical specimens and its correlation with clinicopathological data. Let-7d overexpressing breast cancer cell lines combined...