...-1-3p in bladder cancer is yet unknown. Methods: The expression levels of miR-1-3p in bladder cancer tissues and cell lines were examined by qRT-PCR. Bisulfite sequencing PCR was used for DNA methylation analysis. The target of miR-1-3p was validated by a dual luciferase reporter assay...

...Yue-Peng Cao; Jun Zhou; Wei-Jian Li; Yang Shao; Shu-Yun Zheng; Tian Tian; Kai-peng Xie; Xiang Yan Background/Aims: Bladder cancer (BC) is one of the most frequent urologic tumors worldwide. However, long non-coding RNA(lncRNA) expression profiles in BC progression remain unclear. This study aimed...

...Xiaoliang Chen; Chunshu Jia; Chunyi Jia; Xingyi Jin; Xinquan Gu Background/Aims: microRNA (miR)-374a plays a crucial role in cancer progression by promoting the metastasis and proliferation of various types of malignant tumors. Because its role in bladder cancer is unknown, we investigated whether...

...Xiaobing Liu; Xin Liu; Yuqi Wu; Zhenqiang Fang; Qingjian Wu; Chao Wu; Yaxing Hao; Xia Yang; Jiang Zhao; Jia Li; Qingqing Wang; Zhenxing Yang; Jie Xu; Xiaoyan Hu; Mingjia Tan; Longkun Li Background/Aims: Chemoresistance is largely responsible for relapses of bladder cancer during clinical therapy...

...Teng Hou; Lijie Zhou; Longwang Wang; Gallina Kazobinka; Yumao Chen; Xiaoping Zhang; Zhaohui Chen Background/Aims: Leupaxin (LPXN) is a member of the paxillin protein family. Several studies have reported that LPXN regulates cancer development; however, the role of LPXN in bladder cancer remains...

... and promising platform for cancer detection and resection. White-light cystoscopy and random bladder biopsies remain the most appropriate but nonetheless suboptimal diagnostic technique for bladder cancer, which is associated with high morbidity and recurrence. However, white-light cystoscopy has intrinsic...

...Peng Li; Xiao Yang; Wenbo Yuan; Chengdi Yang; Xiaolei Zhang; Jie Han; Jingzi Wang; Xiaheng Deng; Haiwei Yang; Pengchao Li; Jun Tao; Qiang Lu; Min Gu Background/Aims: CircRNAs regulate gene expression in different malignancies. However, the role of Cdr1as in the tumourigenesis of bladder cancer...

... NLR in bladder cancer and metastatic or unresectable urothelial carcinoma (mUC or uUC) patients up to July 2017. The correlation between the pretreatment NLR and pathological characteristics was also evaluated in bladder cancer patients. Methods: The hazard ratio (HR) and odds ratio (OR) with the 95...

...Cong Li; Xing Zeng; Zheng Liu; Fan Li; Kun Wang; Baisen Wu Background/Aims: Emerging studies on brain-derived neurotrophic factor (BDNF) have shown that might be novel biomarkers and therapeutic targets for cancer. We explore the role of BDNF in the tumorigenesis of bladder cancer...

... the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on autophagy inhibition and apoptosis induction. Methods: Bladder cancer cell lines were irradiated with or without chloroquine. Cell proliferation was determined by a Cell Counting Kit 8 assay. The radiosensitization effect of chloroquine...

...Hui-Jin Li; Xiao-Min Sun; Zheng-Kun Li; Qian-Wen Yin; Huan Pang; Jing-Jing Pan; Xu Li; Wei Chen Background/Aims: This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and to explore how UCA1 participates...

...Bo Fan; Xiaoyu Zhang; Yongliang Ma; Aili Zhang Background/Aims: Tetrandrine and Fangchinoline (Fcn) are two natural products that are found in Stephania tetrandra . Tetrandrine is a known anti-bladder cancer compound, but the effects of Fcn on bladder cancer have been previously unclear...

... in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines...

... and invasion through targeting multiple genes. However, the molecular biological function in bladder cancer has not been clearly elucidated. The aim of this study is to explore ROR expression levels and evaluated its function in bladder cancer. Methods: LncRNA ROR expression levels in the 36 pairs of bladder...

...Wei Qiu; Jun Lin; Yichen Zhu; Jian Zhang; Liping Zeng; Ming Su; Ye Tian Background: Genomic DNA methylation plays an important role in both the occurrence and development of bladder cancer. Kaempferol (Kae), a natural flavonoid that is present in many fruits and vegetables, exhibits potent anti...

... in the regulation of diverse processes in cancer cells. However, the involvement of miR-218 in chemo-sensitivity to cisplatin and the precise mechanism of this action remained unknown in bladder cancer. Methods: qRT-PCR was used to detect miR-218 and its target Glut1 expression in bladder cancer cell lines T24...

...Yi Zhi; Jinhong Pan; Wenhao Shen; Peng He; Ji Zheng; Xiaozhou Zhou; Gensheng Lu; Zhiwen Chen; Zhansong Zhou Background/Aims: Ginkgolide B (GB) is currently used as an anticancer drug for treatment of some malignant cancers. However, whether it may have therapeutic effects on bladder cancer remains...

...Zhen Gong; Hanzi Xu; Yiping Su; Wangfei Wu; Lin Hao; Conghui Han Background/Aims: The aim of this study was to develop a novel model by transplanting human bladder cancer xenografts into humanized immunodeficient mice (SCID). Methods: The animals first underwent sublethal irradiation and then were...