... the understanding of lncRNA-related ceRNA networks in PCC and suggests that the lncRNAs C9orf147 and BSN-AS2 could be independent prognostic biomarkers and potential therapeutic targets for PCC. [email protected] 5 06 2018 6 12 2018 14 12 2018 Pheochromocytoma (PCC...

... needed. We aimed to identify potential long non-coding RNAs (lncRNAs) in circulatory exosomes that may serve as biomarkers for the detection of early-stage CRC. Methods: Exosomes from the plasma of CRC patients (n = 50) and healthy individuals (n = 50) were isolated by ultracentrifugation, followed...

...Cheng Zhang; Yu Liang; Ming-Hui Ma; Kun-Zhe Wu; Chun-Dong Zhang; Dong-Qiu Dai Background/Aims: MicroRNAs have a significant role in the tumorigenesis and progression of cancers, including gastric cancer (GC). Our study aimed to identify a novel biomarker to predict the prognosis of patients with GC...

... characterized. Methods: We investigated the levels of circRNAs in patients with HCC to identify potential diagnostic biomarkers. We examined circRNA expression profiles in liver tumors and paired non-cancerous liver tissues from three HCC patients with cancer thrombus using a circRNA microarray. Bioinformatics...

...Xiaojing Guo; Jialei Yang; Baoyun Liang; Tingting Shen; Yan Yan; Siyun Huang; Jinying Zhou; Jiao Huang; Lian Gu; Li Su Background/Aims: Long non-coding RNAs (lncRNAs) are potential biomarkers of tumors, cardiac disease, and cerebral disease because of their interaction with coding RNAs. This work...

... of this protein could be a clinically useful prognostic biomarker. [email protected] 8 01 2018 24 09 2018 2 10 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons...

... statistically significant. Zinc antiviral protein ZAP Hepatocellular carcinoma Prognosis Biomarker Hepatocellular carcinoma (HCC) is the third most common malignancy worldwide and the second leading cause of cancer-related deaths [ 1 ]. The occurrence and development of HCC are associated...

...). However current diagnostic and therapeutic modalities against NSCLC are ineffective due to incomplete understanding of molecular pathogenesis of NSCLC. Emerging evidence shows that long non-coding RNAs (lncRNAs) can function as biomarkers for diagnosis and prognosis. LncRNAs can control transcription...

... ], but not able to predict patients who would be benefit from adjuvant chemotherapy. Therefore, it is necessary to identify biomarkers that can be used to guide personalized therapy, exempting those patients from unnecessary potential exposure to toxicity and the financial burden of chemotherapy treatments...

... that hsa-miR-27b-3p (miR-27b) was up-regulated in KD serum. However, the specific role of miR-27b in KD remains unclear. We aimed to investigate that miR-27b could be a biomarker and therapeutic target for KD treatment. As well, the specific mechanism of miR-27b effecting endothelial cell functions...

... reclassification index increased significantly after addition of CCN1 (23.9%, p =0.0179). Conclusions : CCN1 is strongly predictive of 6-month mortality in patients with AHF, suggesting serum CCN1 as a promising candidate prognostic biomarker for AHF patients. [email protected] 4 10 2017 6...

... and 0.962 in training set and validation set respectively. Conclusions: Circulating XLOC_014172 and RP11-230G5.2 may act as novel biomarkers in GDM patients as fingerprint for the risk of macrosomia outcome. [email protected] 29 12 2017 25 05 2018 23 7 2018 © 2018 The Author(s...

... functional outcomes in Chinese patients with stroke. Cerebrovascular Stroke Serum Uric acid Biomarker Association Stroke is a more common and frequently occurring disease in middle and old aged people in China. The age-standardized incidence and mortality rates were 1114.8 per 100, 000 people...

... (OSCC). This study aimed to determine the expression of circRNAs in the saliva of OSCC patients to identify novel biomarkers for OSCC screening. Methods: Microarray screening of circRNA was performed to identify differentially expressed circRNAs in saliva from 3 OSCC patients compared with 3 healthy...

... occurs during tumorigenesis [ 21 ]. Breast cancer Let-7d Jab1 COPS5 CSN5 Biomarker Let-7 family, including let-7d, was reported to inhibit tumor pathogenesis [ 20, 22 ]. On the other hand, let-7d contributes to the pathogenesis of some cancers. For instance, it was reported that let-7d...

..., and poor prognosis. In the current study, we investigated the use of long non-coding RNAs (lncRNAs), tumor-specific growth factor (TSGF), and squamous cell carcinoma antigen (SCCA) as potential biomarkers for OSCC screening. Methods: LncRNA expression was measured by microarray analysis in three sets...

...Kewei Zhao; Qing Zhao; Zhaodi Guo; Zhixiang Chen; Yanwei Hu; Jing Su; Lian Chen; Zhiliang He; Xiuping Cai; Minyuan Chen; Lei Zheng; Wen Wang; Qian Wang Background/Aims: Circular RNAs (circRNAs) serve as potential diagnostic biomarkers. In this study, we aimed to identify a potential biomarker from...

...Tao Wu; Yichen Chen; Yantao Du; Jin Tao; Zhong Zhou; Zhuo Yang Background/Aims: MicroRNAs (miRNAs) can be used as biomarkers for cardiovascular diseases, especially for heart failure. However, there are few reports on serum exosomal miRNA biomarkers in patients with acute heart failure (AHF) due...

... Biomarker Osteosarcoma is the most common primary malignancy of bone and frequently occurs in young adults and adolescents [ 1, 2 ]. With the advancement of radical surgery and neoadjuvant chemotherapy, the survival rates of osteosarcoma patients have dramatically improved in recent decades [ 3-6...

... ratio was 8.38 (95% CI: 6.86-10.25), and the overall area under the curve was 0.81 (95% CI: 0.77-0.84), indicating good discriminative ability of circRNAs as biomarkers for digestive system malignancy. Conclusion: circRNAs distinguish patients with digestive system cancer from controls with relatively...