...) in a variety of cancer types including breast and lung cancer cells. Here, we demonstrated the inhibitory effect of berberine (BBR) on tumor growth and metastasis of triple negative breast cancer (TNBC) cells via suppression of TGF-β1 expression. Methods: The levels of mRNA expression were analyzed by real...

... efficacies of current antibiotics. Methods: The antimicrobial effects of azithromycin (AZM) and berberine (BER) alone and in combination were evaluated using microdilution method, checkerboard assay, time-kill test, qRT-PCR analysis and absorption method. The treatments of AZM and/or BER were further...

...Bin Wang; Xianlin Xu; Xiaozhou He; Zhigang Wang; Min Yang Background/Aims: Berberine, a naturally occurring isoquinoline alkaloid, acts against oxidative stress (OS) and endoplasmic reticulum stress (ERS), both of which are responsible for Aldosterone (Aldo) -induced podocyte injury. However...

...Qiaoyun Chen; Rong Qin; Yue Fang; Hao Li Background: Berberine, a well-known component of the Chinese herbal medicine Huanglian, has wide range of biochemical and pharmacological effects, including antineoplastic effect, but the exact mechanisms remain unclear. The aim of the present study...

... by various pro-arrhythmic drugs. Berberine (BBR) was previously found to acutely inhibit hERG currents and prolong action potential duration. The present study aimed to determine long-term effects of BBR on the expression of 135kDa/155kDa hERG and the mechanism. Methods and Results: hERG expression...

...Sangmin Kim; Soo-Jin Oh; Jeongmin Lee; Jeonghun Han; Myeongjin Jeon; Taewoo Jung; Se Kyung Lee; Soo Youn Bae; Jiyoung Kim; Won Ho Gil; Seok Won Kim; Jeong Eon Lee; Seok Jin Nam Background/Aims: Berberine (BBR) is an isoquinoline alkaloid and is beneficial for the anticancer effect on a variety...

...Jian Liu; Xiaoling Zhang; Aiguo Liu; Shuangyou Liu; Liuqing Zhang; Bei Wu; Qun Hu Background: Berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. However, the underlying molecular mechanisms of berberine induced p53-independent apoptosis remain unclear...