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Keywords: Autophagy
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Cellular Physiology and Biochemistry (2018) 51 (4): 1863–1878.
Published Online: 30 November 2018
...Qi Liang; Yuanyuan Xiao; Kaihua Liu; Caigao Zhong; Ming Zeng; Fang Xiao Background/Aims: Hexavalent chromium [Cr(VI)] pollution has become a global concern for both ecosystems and human health. Our previous study revealed Cr(VI) could induce both apoptosis and autophagy in L-02 hepatocytes. Here...
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Cellular Physiology and Biochemistry (2018) 51 (4): 1751–1762.
Published Online: 30 November 2018
...-inflammatory factors were assessed using real-time PCR. The renal apoptotic pathway was evaluated with TUNEL staining and western blot. Mitochondrial dysfunction (MtD) was determined using real-time PCR and electron microscopy. The activation of autophagy was detected using western blot. Results: In the Ang II...
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Cellular Physiology and Biochemistry (2018) 51 (4): 1566–1583.
Published Online: 29 November 2018
... molecular signalling mechanisms in vitro and in vivo Methods: Cell viability and proliferation were detected with MTT and colony formation assays. Morphological changes associated with autophagy were assessed by transmission electron microscopy (TEM). The cell cycle rate was measured by flow cytometry...
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Cellular Physiology and Biochemistry (2018) 51 (2): 897–908.
Published Online: 22 November 2018
... to inhibit the process of liver fibrosis. This study aimed to investigate the underlying mechanism of methyl helicterate (MH) isolated from Helicteres angustifolia on the activation of HSCs. Methods: HSC-T6 cells were treated with various concentration of MH and autophagy was inhibited by 3-Methyl adenine (3...
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Cellular Physiology and Biochemistry (2018) 51 (2): 778–792.
Published Online: 21 November 2018
... and have been shown to participate in a new avenue of cell death-autophagy, which can play a significant role in several types of heart disease. Methods: MicroRNAome analysis showed that the expression of miR-2954 was increased in the myocardium of selenium-deficient chickens, and PI3K was predicted...
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Cellular Physiology and Biochemistry (2018) 51 (2): 528–542.
Published Online: 20 November 2018
... ERK to destroy microtubules and inhibit cell growth in lung cancer cells. However, the underlying mechanisms are unclear, and it is unknown whether SFN-NAC can inhibit the growth of glioma. Here, we have demonstrated for the first time that SFN-NAC activates autophagy-mediated downregulation of α...
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Cellular Physiology and Biochemistry (2018) 50 (5): 1673–1686.
Published Online: 01 November 2018
... autophagy. Conclusion: Up-regulating Trx inhibited neurodegeneration induced by AGEs. The underlying mechanism may be related to inhibit Txnip/mTOR pathway-mediated autophagy. kongli@dmu.edu.cn 26 05 2018 24 10 2018 1 11 2018 © 2018 The Author(s). Published by S. Karger AG...
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Cellular Physiology and Biochemistry (2018) 49 (4): 1352–1363.
Published Online: 11 September 2018
...) in lipopolysaccharide (LPS)-induced autophagy of human intestinal epithelial cells as well as the underlying mechanisms. Methods: Cell viability and expression of proteins related to autophagy, AMPK and the mTOR pathway in LPS-treated Caco-2 cells were determined by CCK-8 assay and Western blot analysis, respectively...
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Cellular Physiology and Biochemistry (2018) 49 (1): 335–348.
Published Online: 23 August 2018
...Yuan Gao; Weiwei Qi; Libin Sun; Jing Lv; Wensheng Qiu; Shihai Liu Background/Aims: Previous studies have shown that FOXO3, a member of the forkhead box O (FOXO) family, regulates autophagy in various cells. To date, whether the induction of autophagy in gastric cancer (GC) cells is triggered...