... of atherosclerosis. The aim of the present study was to investigate the potential roles of salusin-α in the functions of VSMCs during the development of atherosclerosis. Methods: In vivo , the effects of salusin-α on atherogenesis were examined in rabbits fed a cholesterol diet. The aortas were en face stained...

... with unclear mechanisms. We investigated the effect of olanzapine on atherosclerosis and the mechanisms in apolipoprotein E-null (apoE -/- ) mice. Methods: ApoE -/- mice were used as in vivo models. Western blot analysis was used to evaluate protein expression. Conventional assay kits were applied to assess...

... abnormalities in the development of atherosclerosis and hypertension. Myeloperoxidase (MPO) is involved in ROS modifications, triggering lipid peroxidation and aldehyde formation. However, the relationship between the entirety of the MPO reaction system and oxidative modification of serum lipoproteins...

...Yu-Qing Huang; Jie Li; Cheng Huang; Ying-Qing Feng Background/Aims: Atherosclerosis is a serious disease that increases the risk of myocardial infarction and ischemic stroke. Previous studies have demonstrated that microRNA (miR)-29c could play significant roles in atherosclerosis via regulating...

...Zheng Shen; Qiang She Background/Aims: LncRNA is a growth arrest-specific transcript 5 (GAS5) with tumor suppressor activities in some cancers, but its role in atherosclerosis is unclear. Methods: Bioinformatics algorithm analysis was utilized to search the target of GAS5 and miR-21, followed...

... secretion and also the atherosclerosis process. Conclusion: Thus our data showed that IL-38 might present protective effects on hyperlipidemia treatment. qinqintch@163.com 18 09 2017 21 08 2018 30 8 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access...

..., instructions or products referred to in the content or advertisements. Microbiota Endothelial dysfunction Baroreflex Insulin resistance Hypertension Dyslipidemia Atherosclerosis While infectious diseases were the most important health issue in the world until the beginning of the 20 th...

...Yan Sun; Dai Zhang; Xiaoli Liu; Xuesong Li; Fang Liu; Yi Yu; Shuo Jia; Yujie Zhou; Yingxin Zhao Background/Aims: Endoplasmic reticulum (ER) stress is an important event in atherosclerosis. Recent studies have shown that ER stress deregulates cholesterol metabolism via multiple pathways. This study...

... as a key player in the development of atherosclerosis. However, the mechanisms of how C/EBPβ regulates the production of IL-1β are unclear. In this study, we aimed to explore the role of C/EBPβ in regulating IL-1β production in macrophages after oxidized low-density lipoprotein (ox-LDL) exposure...

...Kun Ren; Ting Jiang; Hui-Fang Zhou; Yin Liang; Guo-Jun Zhao Background/Aims: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood vessel walls. ABCA1 plays a crucial role in mediating cholesterol efflux from macrophages, which protects...

...Dachuan Shen; Lili Tian; Tingting Shen; Huijun Sun; Pixu Liu Background/Aims: Diseases caused by atherosclerosis are the leading causes of death in postmenopausal women, owing to the loss of estradiol. Hormone replacement therapy (HRT) provides short-term beneficial effects in the treatment...

...Bing Qin; Yaqing Shu; Ling Long; Haiyan Li; Xuejiao Men; Li Feng; Huan Yang; Zhengqi Lu Background/Aims: Atherosclerosis, a multifactorial chronic disease, is the main cause of death and impairment in the world. Endothelial cells (ECs) apoptosis plays a crucial role in the onset and development...

...Shouzhu Xu; Jing Zhao; Juntian Liu; Wei Gou Background/Aims: Atherosclerosis is a chronic inflammatory disease in the artery walls. Fibrinopeptide A (FPA) is a biomarker of the activation of coagulation system, and a high concentration of FPA in blood occurs in patients with ischemic heart disease...

... for various types of diseases including AS (Atherosclerosis). The hepcidin-ferroportin axis plays the key role in regulation of iron homeostasis and modulation of this signaling could be a potential therapeutic strategy in the treatment of these diseases. TMP (Tetramethylpyrazine) has been reported to have...

... cell apoptosis and stabilizes atherosclerosis (AS) plaques in animal models. Lymphocytes also play vital roles in the development of AS. The primary purpose of the present study was to investigate the effects of ALA-SDT on T helper (Th) cell fate and function, Th subset differentiation...

...-associated insulin resistance and atherosclerosis. However, the molecular mechanisms underlying T-cell-mediated inflammation in adipose tissue remain largely unknown. Methods: Sixty apolipoprotein E (ApoE -/- ) mice were randomly divided into chow and diabetes groups. Diabetes was induced by a high-fat...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. abreb@ump.edu.pl Human arterial endothelial cells Senescence Atherosclerosis Sulodexide Cellular Physiology Cell Physiol Biochem...

... and treatment of atherogenesis is feasible. The aim of this study is to investigate the effect of the 18-kDa FGF-2 isoform on atherosclerosis progression in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice. Methods: We established a model of atherosclerosis using ApoE and 18-kDa FGF-2 gene double...

...Xinye Liu; Lingxu Wang; Hao Chi; Jin Wang; Qian Zheng; Jingye Li; Yong Li; Dongwei Yang Background/Aims: The association between the genetic polymorphisms located in either the exon or untranslated region of MTHFR and the risk of human atherosclerosis has been well-documented. This study analyzed...

...Jing Liu; Jibin Lin; Shaolin He; Chun Wu; Boyuan Wang; Jie Liu; Yanping Duan; Tianxiao Liu; Shengshuai Shan; Keping Yang; Nianguo Dong; Qingwei Ji; Kai Huang; Dazhu Li Background/Aims: Recently, studies have shown that interleukin-37 (IL-37) is involved in atherosclerosis-related diseases. However...