...Lin Wang; Shuang Pei; Linlin Han; Bin Guo; Yanfei Li; Ranran Duan; Yaobing Yao; Bohan Xue; Xuemei Chen; Yanjie Jia Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related...

... in the central nervous system associated with demyelination and axonal injury. Astrocyte activation is involved in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. This study was designed to find potential lncRNAs in EAE mice and activated astrocytes. Methods: we...

...Hyunju Park; So-Hee Ahn; Yieun Jung; Joo Chun Yoon; Youn-Hee Choi Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes. An anti...

... astrocytes. Methods: The primary rat astrocytes were randomly divided into 6 groups, blank control, OGD/R, OGD/R+PYC (10, 20, 40, and 60 µg/mL). The cell activity were detected by MTT and LDH assays, then the levels of oxidant products [malondialdehyde (MDA) and reactive oxygen species (ROS)] , antioxidants...

...Nana Li; Xiang Zhang; Hongquan Dong; Susu Zhang; Jie Sun; Yanning Qian Background/Aims: Astrocytes are critical for the development of postoperative cognitive dysfunction (POCD). In addition, astrocytes express toll-like receptors 4 (TLR4) and build up responses to innate immune triggers...

... diabetes-related microvascular and macrovascular complications as well as comorbidities such as neurodegenerative disorders. In the present study, we investigated the effects of liraglutide on primary rat cortical astrocytes treated with advanced glycation end-products (AGEs). Methods : Gene and protein...

...Li Liu; Qi You; Yingfeng Tu; Quanyi Li; Lihong Zheng; Xuan Li; Jing Gu; Guonian Wang Background: There is an increasing interest in the role of astrocytes contributing to the intrinsic bioremediation of ischemic brain injury. The purpose of this study was to disclose the effects and mechanism...

..., stimulation of the progression of gliomas, and regulation of the immune response of astrocytes. Methods: We have investigated the role of Fas/CD95 in the regulation of the proliferation of fetal astrocytes in vitro , as well as the signalling pathways involved. Results: Fas/CD95 ligation stimulated...

... of Medicine, University of Prishtina, Prishtinë, 3Department of Chemistry, University of Prishtina, Prishtinë Key Words Astrocytes Neuroexcitability Neurotransmission Excitatory amino acid transporter Leptin Erythropoietin Abstract The Janus-activated kinase-2 JAK2 is involved in the signaling...

...Eva-Maria Gehring; Agathe Zürn; Fabian Klaus; Joerg Laufer; Mentor Sopjani; Ricco Lindner; Nathalie Strutz-Seebohm; Jeremy M. Tavaré; Christoph Boehmer; Monica Palmada; Undine E. Lang; Guiscard Seebohm; Florian Lang The Na + ,glutamate cotransporter EAAT2 is expressed in astrocytes and clears...

...Richard Fischer; Anne Rühl; Ralf Kubitz; Dieter Häussinger Background: Enteric glial cells show morphological similarities to astrocytes, but little is known about their regulation. Methods: The effects of various agonists on intracellular Ca 2+ were studied by means of fura-2 fluorescence...