...-Dihydroxyvitamin D3 Mitochondrial dysfunction Autophagy Angiotensin II End-stage renal disease (ESRD) is the last phase of chronic kidney disease (CKD). The prevalence of ESRD is increasing worldwide, which is a problem for the healthcare system of different countries [ 1 ]. The renin–angiotensin...

...Dawei Lian; Jieqing Lai; Yanjiao Wu; Lei Wang; Yongjun Chen; Yang Zhang; Krishna M. Boini; Yi Huang; Yang Chen Background/Aims: Angiotensin II (Ang II) is an octapeptide hormone that plays a significant role in mediating hypertension. Although hypertension is considered a chronic inflammatory...

...Yun-Long Zhang; Lian-Yun Zhi; Lei-Xin Zou; Chen Chen; Jie Bai; Qiu-Yue Lin; Song Lai; Lei Wang; Ying Liu; Hui-Hua Li Background/Aims: Angiotensin II (Ang II)-mediated hypertension is a major risk factor for cardiovascular diseases. Ang II induces changes in vessel structure and function through...

... of capillary network series connected by efferent arterioles. Angiotensin II constricts the efferent glomerular artery. Hence, renal tumor blood flow (BF) distribution may be different from tumors in other organs. This study aims to investigate the effects of angiotensin II on the hemodynamics of intrarenal...

...Shipeng Wang; Xia Gu; Qi Zhang; Xiling Zhang; Yilan Li; Yuan Yao; Bo Yu; Yao Zhang Background/Aims: Angiotensin II (Ang II) regulates the expression of some core clock genes; excess Ang II leads to atherosclerosis advancement. Macrophage Rev-erbα mediates clockwork and inflammation, and plays...

...Xian-Yun Qin; Yun-Long Zhang; Ya-Fei Chi; Bo Yan; Xiang-Jun Zeng; Hui-Hua Li; Ying Liu Background/Aims: Naive CD4 + T cells differentiate into T helper cells (Th1 and Th2) that play an essential role in the cardiovascular diseases. However, the molecular mechanism by which angiotensin II (Ang II...

...Shun Wang; Mian Cheng; Zhengqing Hu; Shan Hu; Qiang Zou; Xin Lai; Beilei Liu; Hong Jiang; Congxin Huang; Gang Wu Background/Aims: Angiotensin II (Ang II) has been shown to promote cardiac remodeling during the process of hypertrophy. Myosin light chain kinase (MLCK), a specific kinase...

...Yuan Liu; Lu Gao; Sen Guo; Yuzhou Liu; Xiaoyan Zhao; Ran Li; Xiaofei Yan; Yunpeng Li; Shuai Wang; Xiaoyu Niu; Liantao Yao; Yanzhou Zhang; Ling Li; Haibo Yang Background/Aims: Endothelial-to-mesenchymal transition (EndMT) is a mechanism that promotes cardiac fibrosis induced by Angiotensin II (AngII...

...Wen Ji Li; Mingxi Xu; Meng Gu; Da-chao Zheng; Jianhua Guo; Zhikang Cai; Zhong Wang Background/Aims: Transforming growth factor-β1 (TGF-β1) plays important roles in penile corporal fibrosis and veno-occlusive dysfunction (CVOD). Angiotensin II (Ang II) is critically involved in erectile dysfunction...

... analyses. Results: 1µM EPI significantly inhibited 1µM angiotensin II (Ang II)-induced increase of cardiomyocyte size, as well as the mRNA and protein levels of ANP, BNP and β-MHC in vitro . The effects of EPI were accompanied with an up-regulation of SP1 and SIRT1, and were abolished by SP1 inhibition. Up...

... is known about its role on adventitial remodeling. Methods: We used C57BL/6J mice in vivo and primary rat adventitial fibroblasts (AFs) in vitro treated with Angiotensin II to investigate the effects of CYP2J2 gene delivery and exogenous EETs administration on adventitial remodeling. Results: CYP/sEH...

...Yuanyuan Ji; Zhidong Wang; Zongfang Li; Aijun Zhang; Yaofeng Jin; Haiyan Chen; Xiaofeng Le Background/Aims : The pathogenesis of hepatocellular carcinoma (HCC) is mainly characterized by persistent cycles of liver injury, inflammation, and compensatory hepatocyte proliferation. Angiotensin II (Ang...

...Guoliang Jiang; Hui Gong; Yuhong Niu; Chunjie Yang; Shijun Wang; Zhidan Chen; Yong Ye; Ning Zhou; Guoping Zhang; Junbo Ge; Yunzeng Zou Background/Aims: Angiotensin II (AngII) type 1 receptor (AT 1 R) could be activated by mechanical stress without the involvement of AngII during the development...

...Andrea F. Gil Lorenzo; Valeria V. Costantino; Martin López Appiolaza; Valeria Cacciamani; Maria E. Benardon; Victoria Bocanegra; Patricia G. Vallés Background: Angiotensin II/Angiotensin II type 1 receptor (AT 1 R) effects are dependent on ROS production stimulated by NADPH oxidase activation...

...Lei Liu; Jianqiang Geng; Hongwei Zhao; Fengxiang Yun; Xiaoyu Wang; Sen Yan; Xue Ding; Wenpeng Li; Dingyu Wang; Jianqiang Li; Zhenwei Pan; Yongtai Gong; Xiangyang Tan; Yue Li Background/Aims: Angiotensin II receptor blockers (ARBs) have been proved to be effective in preventing atrial structural...

...) Angiotensin II ICAM-1 VCAM-1 MCP-1 Atherosclerotic cardiovascular diseases such as coronary heart disease (CHD), peripheral artery disease, and carotid artery stenosis are leading causes of morbidity and mortality. Atherosclerosis is a chronic inflammatory disease [ 1 ]. Monocytes adhere...

...Yan Meng; Chen Chen; Cui Tian; Jie Du; Hui-Hua Li Background/Aims: Angiotensin II (Ang II) plays a critical role in regulating vascular inflammatory diseases, such as atherosclerosis and hypertension. Early growth response-1 (Egr-1) is an immediate early gene that acts as a master switch...

...Meng-Qiu Dang; Xue-Chen Zhao; Song Lai; Xia Wang; Lei Wang; Yun-Long Zhang; Yang Liu; Xiao-Hong Yu; Ying Liu; Hui-Hua Li; Yun-Long Xia Background/Aims: Angiotensin II (Ang II) plays a critical role in the cardiac remodeling contributing to heart failure. However, the gene expression profiles...

...Jing-Si Zhang; Yun-Long Zhang; Hong-Xia Wang; Yun-Long Xia; Lei Wang; Yi-Nong Jiang; Hui-Hua Li; Ying Liu Background/Aims: Angiotensin II (Ang II) mediated signaling plays a key role in the development of chronic kidney damage that contributes to renal fibrosis. However, the gene expression changes...

...Jia Di; Lei Jiang; Yang Zhou; Hongdi Cao; Li Fang; Ping Wen; Xiurong Li; Chunsun Dai; Junwei Yang Background: Fibroblast activation is one of the most important mechanisms for Angiotensin II (Ang II) in promoting renal fibrosis. Transcription factor Ets-1 is recognized to play a key role in kidney...