... collected from Balb/c mice infected with E. granulosus and normal mice (control) and cultured in vitro . Human umbilical vein endothelial cells (HUVECs) were stimulated with the cell supernatant, and angiogenesis was investigated and analysed by the Angiogenesis module of the software NIH Image J. RNA...

...Mingyan Li; Yongsheng Cui; Wenkai He; Xiufang Deng; Yuting Wang; Meifeng Cai; Yuegang Wang; Jingxian Pei; Xiao Mei; Pingsheng Wu Background/Aims: The effects of hypoxia-inducible factor-1α (HIF-1α) on angiogenesis and cardiac function improvement in rats with myocardial infarction (MI) is unknown...

... to block the fusion of preosteoclasts into mature osteoclasts. However, it is unclear whether inhibition of SHP-2 could promote preosteoclast-induced angiogenesis and then enhance bone formation. This study aimed to determine the effects of a specific SHP-2 inhibitor (NSC-87877) on CD31 hi Emcn hi vessel...

.... Panax quinquefolium saponins Chronic myocardial ischemia Angiogenesis Proteomics Despite recent advancements in interventional therapies, including coronary artery bypass grafting (CABG) and percutaneous coronary interventions (PCI), coronary artery disease (CAD) remains the leading cause...

...Guang Wang; Pei-zhi Li; Shi-yao Zhang; Shan Zhong; Chang Chu; Shufei Zeng; Yu Yan; Xin Cheng; Manli Chuai; Berthold Hocher; Xuesong Yang Background/Aims: Angiogenesis plays a key role during embryonic development. The vascular endothelin ( ET) system is involved in the regulation of angiogenesis...

...Thomas G. Blanchard; Rena Lapidus; Vivekjyoti Banerjee; Andrea C. Bafford; Steven J. Czinn; Hafiz Ahmed; Aditi Banerjee Background/Aims: Silencing of tumor suppressor genes (TSGs) and promotion of angiogenesis are associated with tumor development and metastasis. However, little is known...

... to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal...

...) suppresses arrhythmic activity and minimizes cardiomyocyte injury. However, how VNS affects angiogenesis/arteriogenesis in infarcted hearts, is poorly understood. Methods: Myocardial infarction (MI) was achieved by ligation of the left anterior descending coronary artery (LAD) in rats. 7 days after LAD...

... unknown. Methods: The expression of LPXN in bladder cancer cells and tissues was determined by real-time PCR, western blotting, and immunohistochemistry, respectively. The biological role of LPXN in bladder cancer cell proliferation, invasion, and angiogenesis was explored both in vitro and in vivo...

... for angiogenesis and wound healing against refractory cutaneous ulcers in mouse and rabbit models. To increase the effectiveness of the mixed sheet, we developed a multilayered mixed sheet. Methods: We assessed the therapeutic effects of multilayered sheets on cutaneous ulcers in mice. Growth factors...

... angiogenesis and the changes of VEGF/Flk1 and Ang-1/Tie-2 signaling in the rat model of DCM. Methods: Diabetic rats were induced by a single intraperitoneal injection of Streptozotocin. 12 weeks after the diabetes induction, the rats with NRG-1 treatment were treated with tail vein injection of NRG-1...

... peripheral neuropathy (DPN) and assessed whether Nrf2 expression in SCs could repair peripheral nerve injury in a rat model. Nrf2, TLR4/NFκB signal pathway and apoptosis relative protein expression were detected by western blot. Apoptosis and angiogenesis were determined by immunofluorescence and tubule...

...DongDong Chai; Lei Zhang; SiWei Xi; YanYong Cheng; Hong Jiang; Rong Hu Background/Aims: Nuclear erythroid 2-related factor-2 (Nrf2) is a major stress-response transcription factor that has been implicated in regulating ischemic angiogenesis. We investigated the effects of Nrf2 in regulating...

...Yan Ding; Lanlan Shan; Wenqing Nai; Xiaojun Lin; Ling Zhou; Xiaoying Dong; Hongyuan Wu; Min Xiao; Xuejuan Zhou; Linlin Wang; Ting Li; You Fu; Yijun Lin; Chunhong Jia; Meng Dai; Xiaochun Bai Background/Aims: The mechanistic target of rapamycin (mTOR) signaling pathway is essential for angiogenesis...

... to in the content or advertisements. glioblastoma-derived mesenchymal stem cells Differentiation Angiogenesis MiRNA modification Gb-MSCs were obtained from tumor specimens from glioblastoma patients (WHO grade III and IV) who were provided informed consent. A pathological diagnosis was made based...

...Fei Xiao; Chuandong Wang; Chenglong Wang; Yuan Gao; Xiaoling Zhang; Xiaodong Chen Background/Aims: During bone repair and remodeling, osteogenesis is coupled with angiogenesis. Bone morphogenetic protein (BMP) antagonists are important modulators of BMP signaling and bone homeostasis. Several...

... with cell structure, angiogenesis and endothelial dysfunction were investigated in distinct pools of multicellular spheroids (MCS), adherent cells (AD) and tubular structures (TS) formed after a 35-day RPM-exposure. Results: Combining morphological and molecular approaches, we found AD, MCS and TS...

... increased EPC function, promoted ischemic brain angiogenesis, protected against cerebral ischemic injury, and improved long-term stroke outcomes in young mice. In addition, transplanted EPCs from cold-exposed mice had a greater ability to reduce cerebral ischemic injury and promote local angiogenesis...

... the inflammation and promoting angiogenesis. nguyen.tran@univ-lorraine.fr 22 05 2017 22 08 2017 27 11 2017 © 2017 The Author(s). Published by S. Karger AG, Basel 2017 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons Attribution...

...Meng Yang; Lei Wang; Xurong Wang; Xuezhi Wang; Zhiqiang Yang; Jianxi Li Background/Aims: Vascular endothelial growth factor (VEGF) has been demonstrated to play a pivotal role in the regulation of angiogenesis in ovarian follicular development, particularly during the preovulatory period. Although...