...Siqi Tang; Bin Yao; Na Li; Shuhuang Lin; Zunnan Huang Background/Aims: The neuropathies Alzheimer’s disease (AD), Parkinson’s disease (PD), and schizophrenia (SCZ) have different pathological mechanisms but share some common neurodegenerative features, such as gradual loss of neuronal structure...

.... Conclusion: ICS II mitigates Aβ 25-35 -induced cognitive deficits and neuronal cell injury by upregulating the BDNF/TrkB/CREB signaling, suggesting that ICS II can be used as a potential therapeutic agent for dementia, such as Alzheimer’s disease. gqh@zmc.edu.cn 13 01 2018 27 08 2018 7...

... of headaches, vomiting, coughing and hangovers. 2-dodecyl-6-methoxycyclohexa-2, 5-1, 4-dione (DMDD) has been isolated from A. carambola L. roots, and this study was carried out to investigate the potential beneficial effects of DMDD on neuron apoptosis and memory deficits in Alzheimer's disease. Methods...

... detoxifying genes. As such, Nrf2 deregulation has been linked to both aging and pathogenesis of many human chronic diseases, including neurodegenerative ones such as Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis. Nrf2 activity is tightly regulated by a fine balance between...

...Lu Zhang; Yu Fang; Xuan Cheng; Yajun Lian; Hongliang Xu; Zhaoshu Zeng; Hongcan Zhu Background: TRPML1 is reported to be involved in the pathogenesis of Alzheimer’s disease (AD) by regulating autophagy; however, the underlying mechanism is not completely clear. Methods: We developed an APP/PS1...

...Mo Wang; Yu Li; Changwei Ni; Guijun Song Background: Increasing evidence indicates that amyloid β oligomer (AβO) is toxic to neurons in Alzheimer’s disease (AD) brain. The aim of the present study is to evaluate the effects of honokiol on AβO-induced learning and memory dysfunction in mice. Methods...

... metabolism. mingwei_w@163.com 10 10 2016 10 02 2017 31 3 2017 Alzheimer’s disease Stress response Transgenic mice Metabolomics Gas chromatography-mass spectrometry © 2017 The Author(s)Published by S. Karger AG, Basel 2017 Open Access License / Drug Dosage...

... evidence also suggests a role of S1P in Alzheimer's disease (AD) [ 19,20,21,22 ]. Intriguingly, S1P in murine neurons stimulates beta-site APP cleaving enzyme (BACE1) that catalyzes the rate-limiting step in the formation of the amyloid peptide (Aβ), a major component of the characteristic extracellular...

... were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo synthesis. Methods: To identify a potential role of γ-secretase and APP...

...Dantao Peng; Xiuqing Pan; Ju Cui; Yueqin Ren; Jiewen Zhang Background: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Peripheral insulin resistance increases the risk for memory impairment and the development of AD. Objective: This study aims to assess changes...

...Stephanie Busch; Liang Wu; Yuxi Feng; Norbert Gretz; Sigrid Hoffmann; Hans-Peter Hammes Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-β and secondary vessel degeneration. In the polycystic...

...-1184. 533. 9 Terry RD: Cell death or synaptic loss in Alzheimer disease. J Neuropathol Exp Neurol 2000;59:1118-1119. 404 Cell Physiol Biochem 2012;29:391-406 Haghani/Shabani/Javan/Motamedi/Janahmadi 2 0 Orbán G, Völgyi K, Juhász G, Penke B, Kékesi KA, Kardos J, Czurkó A: Differ- ent...