... subjects. Due to lack of efficient drug therapy, plant-based bioactive peptides have been studied as alternative strategy in NAFLD and for less toxicity in elderly. To mimic fatty liver in aging conditions, researchers highly commended the genetically engineered strains SAMP8 (senescence-accelerated mice...

.... Results: Surprisingly, we found that these mice gained weight with age due to an increase in fat mass associated with ectopic fat accumulation. In addition, these mice developed an adipocyte hypertrophy, hyperglycemia, hyperinsulinemia, muscle and hepatic insulin resistance. Understanding the molecular...

..., successful isolation and establishment of ovarian stem cells. It has brought more hope than ever of increasing the size of primordial follicle pool, improving ovarian function and delaying ovarian consenescence. Traditional view holds that stem cell aging contributes to the senility of body and organs...

...). The goal of the present study was to determine whether age-related IGFBP4 overexpression is associated with the impaired osteogenic differentiation potential of aged bone marrow derived MSCs. Methods: MSCs were isolated from Sprague-Dawley rats aged 3–26 months. The bone morphogenetic protein (BMP)-2...

.... [email protected] 21 09 2016 21 11 2016 18 1 2017 Synaptic plasticity Repetitive transcranial magnetic stimulation Aging Senescence-accelerated-prone mouse 8 Cognition Hippocampus © 2017 The Author(s)Published by S. Karger AG, Basel 2017 Open Access License / Drug...

...Xiao-meng Xu; Yi-Chun Ning; Wen-juan Wang; Jie-qiong Liu; Xue-yuan Bai; Xue-feng Sun; Guang-yan Cai; Xiang-mei Chen Background: Chronic inflammation is thought to be a determinant of the aging rate and longevity. Caloric restriction (CR) attenuates age-related increases in the systemic levels...

...Hui Wang; Yihua Bei; Jing Shi; Junjie Xiao; Xiangqing Kong Aging has a remarkable impact on the function of the heart, and is independently associated with increased risk for cardiovascular diseases. Cardiac aging is an intrinsic physiological process that results in impaired cardiac function...

...Thomas K. Sin; Benjamin Y. Yung; Parco M. Siu Aging individuals and diabetic patients often exhibit concomitant reductions of skeletal muscle mass/strength and insulin sensitivity, suggesting an intimate link between muscle aging and insulin resistance. Foxo1, a member of the FOXO transcription...

...Yue Zheng; Zhiwei Xu Objectives: Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization. The number and function of EPCs declines as part of aging-associated senescence, thereby potentially contributing to vascular pathologies. Here, we investigated...

...Hui Che; Li-Hua Sun; Fei Guo; Hui-Fang Niu; Xiao-Lin Su; Ya-Nan Bao; Zidong Donna Fu; Huai-lei Liu; Xu Hou; Bao-Feng Yang; Jing Ai Background: Aging is associated with the gradual cognitive decline and shows the typical senile plaque formation in the brain, which results from the aggregation...

...Yunfei Pu; Hexuan Zhang; Peijian Wang; Yu Zhao; Qiang Li; Xing Wei; Yuanting Cui; Jing Sun; Qianhui Shang; Daoyan Liu; Zhiming Zhu Background/Aims: Age-related cerebrovascular dysfunction contributes to stroke, cerebral amyloid angiopathy, cognitive decline and neurodegenerative diseases. One...

...Rocío Guevara; Magdalena Gianotti; Pilar Roca; Jordi Oliver Aging is responsible for the decline in the function of mitochondria and their increase in size and number - adaptive mechanism to restore mitochondrial function. Estrogens increase mitochondrial function, especially in female rats...

.... Citrate synthase activity was profoundly increased at passage 15 but drastically dropped at passages 20 and 25. There were no significant variations in the above parameters between passages 1 and 10 of subculture. This enhancement of glycolytic activity which accompanies the aging (subculture) process...