...Jing Zheng; Tetsuya Asakawa; Yingyu Chen; Zhihong Zheng; Buyuan Chen; Minhui Lin; Tingbo Liu; Jianda Hu Background/Aims: The present study was designed to investigate the expression of multidrug resistance (MDR)-related genes, verify the synergistic effects of baicalin and Adriamycin (ADM...

... in this study. All animal procedures were approved by the Animal Ethics Committee of Jilin University First Hospital (Jilin, China). An optimized dose 10.5 mg/kg body weight of doxorubicin hydrochloride (Adriamycin: ADR, Sigma) or the equal volume of saline as control was injected once via the tail vein...

...Ying Zhu; Jianzhong Wu; Shuchun Li; Rong Ma; Haixia Cao; Minghua Ji; Changwen Jing; Jinhai Tang Objectives: miR-181a is involved in immunity, metabolism, tumor suppression or carcinogenesis reported by many other studies. However, its role in the development of chemosensitivity to adriamycin in low...

... with various renal diseases. The present study was aimed to closer define which pathomechanisms initially cause alterations in glomerular protein metabolism by using the anthracycline antibiotic Adriamycin (ADR) as a model compound to experimentally induce a glomerular lesion. As an alternative multicellular...