... to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD. Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order...

...Jiacai Hu; Junjun Dong; Zhijie Yang; Hao Wu; Na Yang Background/Aims: Adiponectin (Apn) has shown anti-diabetic and anti-inflammatory potential. In the study, we studied and tested the protective effects of Apn against diabetic renal injury and the possible mechanism of these effects. Methods...

...Junzheng Hu; Weiding Cui; Wenxiao Ding; Yanqing Gu; Zhen Wang; Weimin Fan Background/Aims: Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN), secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic...

...Yijian Chen; Yongliang Zheng; Liping Liu; Chuanming Lin; Changfeng Liao; Liuyan Xin; Sisi Zhong; Qilai Cheng; Liqun Zhang Background: Tumor necrosis factor (TNF)-α can upregulate the expression of plasminogen activator inhibitor (PAI)-1, an inhibitor of fibrinolysis. Adiponectin (Adp) antagonizes...

...Ningning Hou; Gang Du; Fang Han; Jin Zhang; Xiaotong Jiao; Xiaodong Sun Aims: To determine whether irisin could improve endothelial dysfunction by regulating heme oxygenase-1(HO-1)/adiponectin axis in perivascular adipose tissue (PVAT) in obesity. Methods: Male C57BL/6 mice were fed with a high-fat...

... as well as the protein and mRNA expressions that were involved in fatty acid synthesis and oxidation including Adiponectin, AMP-activated protein kinase (AMPK) α, peroxisome proliferator-activated receptor (PPAR) α, sterol regulatory element binding protein 1c (SREBP-1c), acetyl-CoA carboxylase (ACC...

...Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Pei-Sen Huang; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen Background/Aims: Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN...

...Fangxin Zeng; Jinyu Shi; Yang Long; Haoming Tian; Xiaoxi Li; Allan Z. Zhao; Rose Fanghong Li; Tao Chen Objective: This study evaluates the association between serum adiponectin concentrations and the risk of endometrial cancer through a comprehensive meta-analysis of currently available clinical...

...Qiruo Gao; Xudong Yao; Junhua Zheng Background/Aims: The current treatments fail to provide satisfactory cure for aggressive prostate cancers (PCs). Hence, further comprehension of PC metastasis is highly appreciated for improving the levels of therapy. We have previously shown that Adiponectin...

... Adiponectin FAT/CD36 Obesity PPARγ Cytosolic glycerol 3-phosphate dehydrogenase Triacylglycerol Obesity, a global health problem, constitutes a heterogeneous disorder caused by the interaction between genetic, environmental, and psychosocial factors [ 1 ]. It is associated with numerous diseases...