... activation and the resulting immune responses can induce acute lung injury (ALI) in the host. Accordingly, one promising approach to the treatment of neutrophil-dominated inflammatory diseases involves therapeutic FPR1 inhibition. Methods: We extracted a potent FPR1 antagonist from Garcinia multiflora Champ...

... are a promising cell source for MSC-based immunotherapy. Methods: Rat acute lung injury (ALI) models induced by Lipopolysaccharide (LPS) were applied to test the immune-modulatory effects of DFSC/DFSC-CM in vivo . The pulmonary permeability was determined by the dry / wet weight ratios of the left upper lung lobe...

...Qiuyue Zhang; Di Wu; Yang Yang; Tingting Liu; Hongyu Liu Background/Aims: Dexmedetomidine (Dex), a specific agonist of α2-adrenoceptor, has been reported to have extensive pharmacological effects. In this study, we focused on the protective effect of Dex on hyperoxia-induced acute lung injury...

...Yi Chen; Lei Wang; Qiuxiang Kang; Xu Zhang; Guifang Yu; Xiaojian Wan; Jiafeng Wang; Keming Zhu Background: Pulmonary endothelial injury is a critical process in the pathogenesis of acute lung injury (ALI) during sepsis. Heat shock protein A12B (HSPA12B) is mainly expressed in endothelial cells...

...Yuan Liu; Junyu Lu; Xiaoya Wang; Liu Chen; Su Liu; Zhiren Zhang; Wei Yao Background: Traumatic brain injury (TBI) can be complicated by TBI-triggered acute lung injury (ALI), in which inflammation plays a central role. It has been reported that an Erythropoietin-derived peptide (pHBSP) was able...

...Shumin Xu; Mingzheng Xu; Guang-Gang Li; Chunmei Wang; Haihan Song; Jianwen Bai Background: Acute lung injury (ALI) is characterized by rapid induction of inflammation at the alveolar-capillary membrane, and immunosuppressive mechanisms were shown to contribute to its resolution. Despite the central...

... client proteins, such as glucocorticoid receptor (GR), it remains unclear if it has a protective role against acute lung injury (ALI). Methods: ALI model was established by the injection of oleic acid (OA) into the tail vein of mice. Lung injury was assessed by histological analysis, lung water content...

... downstream candidates in ALI [ 5,6,7,8 ]; moreover, IL-1β is involved in the regulation of cell permeability and migration [ 3,9 ]. Acute lung injury (ALI) is a major clinical disorder in the United States which affects approximately 200,000 patients annually with 40% mortality [ 1 ]. ALI causes...

...Xiuru Yin; Zuodi Liang; Yue Yun; Ling Pei Background/Aims: Acute lung injury (ALI) and its aggressive stage, acute respiratory distress syndrome (ARDS), are characterized by diffuse damage and increased permeability of the endothelial barrier, leading to alveolar infiltrates and interstitial edema...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FIP200 HMGB1 acetylation Acute lung injury Pulmonary infection Pseudomonas...

..., instructions or products referred to in the content or advertisements. Apoptosis Acute lung injury Acute promyelocytic leukemia Chemotaxis CX3CL1 CX3CR1 Differentiation syndrome Fractalkine Phagocytosis Microparticles Resolution All-trans retinoic acid (ATRA) has been used successfully...

...-negative bacteria, in the lung. To this end, we induced an acute lung injury in wild type and Ksr1-deficient mice by intratracheal instillation of LPS. We found that LPS-induces acute lung injury, as characterized by cytokine expression, neutrophil infiltration and protein extrusion in wildtype mice. Ksr1...

...Jun Sun; Zhi-Bo Han; Wenbin Liao; Shao Guang Yang; ZhouXin Yang; JingXia Yu; Lei Meng; Rong Wu; Zhong Chao Han Background: Systemic and local inflammatory processes play key, mainly detrimental roles in the pathophysiology of acute lung injury (ALI). The present study was designed to determine...