...Juan Huang; Chunxue Gui; Lei Zhang; Feifei Che; Chunsen Wang Background/Aims: Acute myeloid leukemia (AML) is a relapsed and refractory hematological malignancy with a lower morbidity but higher mortality. In addition to hematopoietic stem cell transplantation, chemotherapy is used as the front...

...Yingyu Chen; Donghui Gan; Qinghua Huang; Xiaofeng Luo; Donghong Lin; Jianda Hu Background/Aims: Acute myeloid leukemia (AML) remains a hematologic malignancy with poor survival and a high risk of relapse, which is mainly caused by the emergence of multidrug resistance (MDR). The identification...

.... Recent studies have demonstrated that circRNAs participate in pathogenesis mainly by acting as microRNA (miRNA) sponges. The expression profile of circRNAs in acute myeloid leukemia (AML) has rarely been reported. Methods: Profiles of circRNAs were analyzed using an Arraystar human circRNA microarray...

...Zhiheng Cheng; Yifeng Dai; Yifan Pang; Yang Jiao; Hongmian Zhao; Sun Wu; Lingxiu Zhang; Yuan Zhang; Xiufeng Wang; Lihua Wang; Dong Ma; Tong Qin; Ning Hu; Yijie Zhang; Kai Hu; Qingyi Zhang; Jinlong Shi; Lin Fu Background/Aims: Acute myeloid leukemia (AML) of French-American-British (FAB) subtypes M0...

...Gang-Zhi Zhu; Yong-Long Yang; Yan-Jiao Zhang; Wei Liu; Mu-Peng Li; Wen-Jing Zeng; Xie-Lan Zhao; Xiao-Ping Chen Background/Aims: Acute myeloid leukemia (AML) is a heterogeneous clonal disease and patients with AML who harbor an FMS-like tyrosine kinase 3 ( FLT3 ) mutation present several dilemmas...

... of acute myeloid leukemia cells and the role of ER-stress protein ERP57, a protein disulfide isomerase, in improvement of chemotherapy. Methods: Using MTT assay we studied cytotoxic effects of shikonin on HL-60 cells. The flow cytometry was adopted to examine the shikonin induced mode of cell death in HL...

...Bing Long; Le-Xun Wang; Fei-Meng Zheng; Shu-Ping Lai; Duo-Rong Xu; Yuan Hu; Dong-Jun Lin; Xiang-Zhong Zhang; Lin Dong; Zi-Jie Long; Xiu-Zhen Tong; Quentin Liu Background/Aims: Resistance of leukemia stem cells (LSCs) to chemotherapy in patients with acute myeloid leukemia (AML) causes relapse...

...Rong Zhang; Wei Yang; Ying Chun Li; Guo Jun Zhang; Kun Yao; Rong Hu; Bin Wu Aim: To investigate the possible association between the Osteopontin (OPN) gene polymorphisms and the susceptibility and chemotherapy response of acute myeloid leukemia patients. Methods: A total of 381 patients with de...

... p21 expression on the sensitivity of acute myeloid leukemia cells in response to HDAC inhibitor SAHA treatment and investigated the underlying mechanism. Methods: Stably transfected HL60 cell lines were established in RPMI-1640 with supplementation of G-418. Cell viability was measured by MTT assay...

... in neoplastic transformation. Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML), suggesting a functional role for Ras in leukemogenesis. Methods: We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D...

... to in the content or advertisements. Mitochondria 4- aminopyridine Acute myeloid leukemia Apoptosis Purinergic receptors Original Paper Cellular Physiology Cell Physiol Biochem 2011;28:199-208 and Biochemistry Accepted: June 28, 2011 4-aminopyridine Induces Apoptosis of Human Acute Myeloid Leukemia...