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Keywords: AKT
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Cellular Physiology and Biochemistry (2018) 51 (2): 827–841.
Published Online: 22 November 2018
... hypertrophy was mediated by blocking activation of the AKT signaling pathway. Conclusion: Hyp improves cardiac function and prevents the development of cardiac hypertrophy via AKT signaling. Our results suggest a protective effect of Hyp on pressure overload-induced cardiac remodeling. Taken together, Hyp may...
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Cellular Physiology and Biochemistry (2018) 50 (2): 798–809.
Published Online: 11 October 2018
.... Further studies show that AKT could be the primary resistance factor of AZD5153. Pharmacological inhibition or genetic depletion of AKT induced BRD4 downregulation, sensitizing AZD5153-induced cytotoxicity in PC-3 cells. In vivo , AZD5153 oral administration inhibited PC-3 xenograft tumor growth in nude...
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Cellular Physiology and Biochemistry (2018) 50 (2): 745–756.
Published Online: 11 October 2018
... of autophagy activator rapamycin and was dramatically counteracted by 3-methyladenine, an autophagy inhibitor. Furthermore, PGE1 suppressed the phosphorylation of AKT and mTOR, which negatively regulated autophagy level in VSMCs. In vivo study, PGE1 remarkably improved the endothelium-independent contraction...
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Cellular Physiology and Biochemistry (2018) 50 (1): 121–135.
Published Online: 02 October 2018
... by reducing the PKC-dependent AKT activity and elevating JNK phosphorylation. Since it was thought that GqPCR induces mainly activation of AKT, we undertook to examine how general is this phenomenon and understand its signaling. Methods: We used various cells to follow the phosphorylation of signaling...
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Cellular Physiology and Biochemistry (2018) 49 (5): 2073–2087.
Published Online: 21 September 2018
... apoptosis under HG and/or hypoxic conditions by facilitating the expression of protein phosphatase-1 nuclear targeting subunit (PNUTS), X-linked inhibitor of apoptosis protein (XIAP), p-AKT, p-Bad, increased the Bcl-2/Bax ratio, as well as downregulated cleaved caspase 3 expression. Mechanistically, we...
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Cellular Physiology and Biochemistry (2018) 47 (4): 1617–1629.
Published Online: 27 June 2018
... Liquid Chromatography, the expression levels of tight junction proteins in the intestinal tract and related signaling molecules, such as GPR109A and Akt, in the colon were examined by quantitative real-time PCR or western blot analyses on day 21. Caco-2 cells were used as a colon cell model and cultured...
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Cellular Physiology and Biochemistry (2018) 47 (1): 356–367.
Published Online: 11 May 2018
... and palmitic acid, alone or in combinations, induced ROS production and centrosome amplification. Together, they increased AKT activation as well as the expression, binding and centrosome translation of ROCK1 and 14-3-3σ. Results from further analyses showed that AKT-ROS-dependent upregulations of expression...
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Cellular Physiology and Biochemistry (2018) 46 (4): 1628–1642.
Published Online: 20 April 2018
...-κBp65, p53, Bax and PCNA were detected by Immunohistochemistry. To gain an insight into the molecular signaling mechanisms, we determined the effect of CM on MAPKs, NF-κB and PI3K/Akt/eNOS pathways by Western blotting. Results: CM lowered 5-FU-triggered increase of creatinine, BUN, Kim-1 and NGAL renal...
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Cellular Physiology and Biochemistry (2018) 46 (3): 907–924.
Published Online: 13 April 2018
... increased. Further study showed that the expression levels of ITGα3, ITGαv and ITGβ1, as well as AKT-phosphorylation, ERK-phosphorylation and p38-phosphorylation, were reduced in vivo after CLIC1 knockdown, while ITGα1 was upregulated. Conclusions: We speculate that CLIC1 may play an important role...
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Cellular Physiology and Biochemistry (2018) 46 (2): 618–632.
Published Online: 28 March 2018
... and apoptosis were assessed by immunohistochemistry, CCK-8 and TUNEL, respectively. The protein expressions of caspase-3, p-Akt and p-GSK-3β both in vivo and vitro were assessed by western blotting. Cognitive functions were assessed by Morris Water Maze test and context fear conditioning test at the adult...
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Cellular Physiology and Biochemistry (2017) 44 (4): 1471–1484.
Published Online: 01 December 2017
... in ATC cells. Angiogenesis antibodies array was utilized to detect the expression of angiogenesis-related genes after Apatinib treatment in ATC cells. In addition, we used Akt activator, Akt inhibitor and GSK3β inhibitor to further study the mechanism for how Apatinib suppressed angiogenesis. Results...
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Cellular Physiology and Biochemistry (2017) 44 (3): 1188–1198.
Published Online: 28 November 2017
... as a competing endogenous RNA (ceRNA) for miR-21 and miR-590-5p. These interactions led to repression of AKT pathway and inhibition of HCC cell proliferation and migration. Conclusion: Thus, our data showed that Linc-USP16, as a tumour suppressor, plays an important role in HCC pathogenesis and provides a new...
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