...Hany H. Arab; Samir A. Salama; Ibrahim A. Maghrabi Background/Aims: The clinical utility of 5-fluorouracil (5-FU) is limited by its nephrotoxicity. Camel milk (CM) has previously displayed beneficial effects in toxicant-induced nephropathies. The current study aimed to investigate the potential...

... Intestinal mucositis 5-fluorouracil Oxaliplatin CD4 + CD25 + Foxp3 + Tregs CD4 + CD17A + cells Colorectal cancer Chemotherapy is an effective and widely used treatment in colorectal cancer (CRC), also diffusely adapted as postoperative adjuvant treatment. Oxaliplatin is frequently used as part...

... in the chemoresistance of CRC cells to 5-Fluorouracil (5-FU) is unclear. The aim of this study is to investigate whether miR-149 targets FOXM1 to regulate the 5-FU resistance of CRC. Methods: The qRT-PCR assay was performed to detect the expression of miR-149 in 5-FU-resistant CRC cells (HCT-8/5-FU and LoVo/5-FU...

... differentially expressed in 5-fluorouracil-resistant and their parental cell-lines (HepG2, HepG2/5-FU) by miRNA microarrays. Microarray results were confirmed by validating quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Up-regulation of miR-141 expression resulted in a significant...